{"id":914,"date":"2026-02-04T09:49:19","date_gmt":"2026-02-04T07:49:19","guid":{"rendered":"https:\/\/premiostore.eu\/tippteadus\/"},"modified":"2026-05-20T11:36:21","modified_gmt":"2026-05-20T08:36:21","slug":"ad_free_science","status":"publish","type":"page","link":"https:\/\/premiostore.eu\/en\/ad_free_science\/","title":{"rendered":"AD-FREE SCIENCE"},"content":{"rendered":"<div class=\"ama-block block-accordion\"><div class=\"block__header text-center\"><h2>Educational, advertisement-free short scientific information about high-efficacy, patented, and clinically validated premium support compounds.<\/h2><p>Note: References are based on RDBPC studies (randomized, double-blind, placebo-controlled trials \u2014 the scientific gold standard) or RCT studies (randomized controlled trials), published in peer-reviewed scientific journals.<\/p><\/div><div class=\"block__body\"><div class=\"accordion\" id=\"accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-1\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-1\"><span class=\"accordion-name\">Astaxanthin (AquaCelle\u00ae AstaReal\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-1\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-section-id=\"153wwiw\" data-start=\"0\" data-end=\"57\"><strong>Which positive outcomes were confirmed for AstaReal\u00ae?<\/strong><\/p>\n<ul data-start=\"59\" data-end=\"1024\">\n<li data-section-id=\"15srs8i\" data-start=\"59\" data-end=\"319\"><strong data-start=\"61\" data-end=\"100\">Children\u2019s digital eye strain study<\/strong> (2025, RDBPC):<br data-start=\"115\" data-end=\"118\" \/>A 20% greater reduction in chronic digital eye symptoms was observed compared to the placebo group. Improvements were also detected in eye accommodation ability (stereovision) and pupillary reflexes.<\/li>\n<li data-section-id=\"10apki5\" data-start=\"321\" data-end=\"547\"><strong data-start=\"323\" data-end=\"348\">Muscle soreness study<\/strong> (Barker et al., 2023, RDBPC):<br data-start=\"378\" data-end=\"381\" \/>The astaxanthin group experienced 58% less muscle soreness (DOMS) 24 hours after intense exercise and 32% less soreness 48 hours after exercise compared to placebo.<\/li>\n<li data-section-id=\"1jzeazr\" data-start=\"549\" data-end=\"796\"><strong data-start=\"551\" data-end=\"571\">Heart rate study<\/strong> (Wika et al., 2023, RDBPC):<br data-start=\"599\" data-end=\"602\" \/>In overweight participants, exercise heart rate was reduced by an average of 7%, while carbohydrate oxidation decreased, helping the body utilize fat more efficiently during physical activity.<\/li>\n<li data-section-id=\"edjadd\" data-start=\"798\" data-end=\"1024\"><strong data-start=\"800\" data-end=\"828\">Glucose metabolism study<\/strong> (Urakaze et al., 2021, RCT):<br data-start=\"857\" data-end=\"860\" \/>A positive correlation was identified between increased adiponectin levels (a hormone involved in blood glucose regulation) and reduced LDL cholesterol oxidation.<\/li>\n<\/ul>\n<p data-section-id=\"wv8cei\" data-start=\"1026\" data-end=\"1037\"><strong>Summary<\/strong><\/p>\n<p data-start=\"1039\" data-end=\"1374\" data-is-last-node=\"\" data-is-only-node=\"\">All of the studies mentioned above were evaluated as successful (positive) by both the manufacturer and independent researchers, as they demonstrated the effectiveness of the compound in achieving their primary objectives, including reducing muscle soreness, alleviating eye fatigue, and optimizing heart rate response during exercise.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-2\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-2\"><span class=\"accordion-name\">Berberine (BioBerb\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-2\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"80\"><strong>Pharmacokinetic Clinical Human Study (Highest Bioavailability)<\/strong><\/p>\n<p data-start=\"82\" data-end=\"124\"><strong>Bioavailability and Absorption Study<\/strong><\/p>\n<p data-start=\"126\" data-end=\"344\">A peer-reviewed clinical study demonstrated the direct superiority of BioBerb\u00ae compared to standard berberine. A single low dose (188 mg) of BioBerb\u00ae achieved a record total berberine plasma concentration of 801 ng\/mL.<\/p>\n<p data-start=\"346\" data-end=\"701\">Therefore: BioBerb\u00ae offers up to 3 times higher bioavailability than conventional berberine products, enabling beneficial effects at significantly lower dosages while drastically minimizing gastrointestinal side effects (diarrhea, gas, cramps, and related digestive discomfort), which are common drawbacks of standard berberine due to its poor absorption.<\/p>\n<p data-start=\"703\" data-end=\"759\"><strong>Transferable RDBPC and RCT Metabolic Health Studies<\/strong><\/p>\n<p data-start=\"761\" data-end=\"950\">Because BioBerb\u00ae efficiently delivers berberine into cells, its functional mechanism of action \u2014 particularly AMPK enzyme activation \u2014 is supported by extensive clinical berberine research.<\/p>\n<ul data-start=\"952\" data-end=\"2050\">\n<li data-section-id=\"1k03u1c\" data-start=\"952\" data-end=\"1413\"><strong data-start=\"954\" data-end=\"998\">Blood sugar and glucose control (RDBPC):<\/strong><br data-start=\"998\" data-end=\"1001\" \/>RDBPC studies on berberine in prediabetic patients (including HIMABERB and similar clinical trials) demonstrated that 12 weeks of supplementation significantly reduced fasting blood glucose, improved insulin sensitivity, and lowered glycated hemoglobin (HbA1c) levels by an average of 0.6%. BioBerb\u00ae may achieve these benefits without requiring the 1500 mg doses commonly used with standard berberine products.<\/li>\n<li data-section-id=\"15ei8vz\" data-start=\"1415\" data-end=\"1826\"><strong data-start=\"1417\" data-end=\"1465\">Weight management and fat metabolism (RCTs):<\/strong><br data-start=\"1465\" data-end=\"1468\" \/>Multiple randomized controlled trials confirmed berberine\u2019s ability to inhibit the formation of new fat cells and reduce visceral fat surrounding internal organs. Positive outcomes included an average weight reduction of 1\u20134 kg over 8\u201312 weeks through stimulation of the AMPK enzyme, which promotes the use of sugars and fats for energy instead of storage.<\/li>\n<li data-section-id=\"dzxzpi\" data-start=\"1828\" data-end=\"2050\"><strong data-start=\"1830\" data-end=\"1871\">Cholesterol and lipid levels (RDBPC):<\/strong><br data-start=\"1871\" data-end=\"1874\" \/>Clinical studies demonstrated that berberine increases the number of LDL receptors in the liver, helping reduce \u201cbad\u201d LDL cholesterol levels by approximately 0.4\u20130.65 mmol\/L.<\/li>\n<\/ul>\n<p data-start=\"2052\" data-end=\"2064\"><strong>Summary<\/strong><\/p>\n<p data-start=\"2066\" data-end=\"2463\">The specific clinical study on BioBerb\u00ae confirmed its exceptionally rapid and high absorption into the bloodstream. This makes it an effective and gastrointestinal-friendly option for individuals seeking the clinically demonstrated benefits of berberine observed in RDBPC studies \u2014 including improved blood sugar balance, lower cholesterol levels, and support for reducing metabolic syndrome risk.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-3\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-3\"><span class=\"accordion-name\">Relissa\u00ae (Indena Phytosome\u2122)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-3\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"194\" data-end=\"874\">Relissa\u00ae (patented, higher-bioavailability lemon balm extract with Phytosome\u2122 technology)<br data-start=\"283\" data-end=\"286\" \/>Relissa\u00ae (<em data-start=\"296\" data-end=\"317\">Melissa officinalis<\/em> extract using Indena lecithin-based Phytosome\u2122 technology) has been evaluated in multiple successful RCT and RDBPC clinical human studies. Compared to standard lemon balm extract, Relissa\u00ae significantly improves the bioavailability of active polyphenols (especially rosmarinic acid). This is associated with modulation of GABA metabolism (via GABA-transaminase inhibition), supporting the preservation of the body\u2019s natural calming neurotransmitter GABA. Clinical studies show benefits in sleep quality, stress reduction, anxiety, and emotional exhaustion.<\/p>\n<p data-start=\"876\" data-end=\"1381\"><strong data-start=\"876\" data-end=\"946\">Insomnia symptoms and sleep architecture improvement (RDBPC study)<\/strong><br data-start=\"946\" data-end=\"949\" \/>Study design (NCT05950932): randomized, double-blind, placebo-controlled crossover trial in adults with sleep disturbances, monitored with wearable sleep tracking devices. Positive outcomes: Insomnia Severity Index (ISI) significant improvement (+2.9 points; 9.7 \u2192 6.8, p = 0.003 vs placebo). Deep sleep (SWS) increased by ~15% in slow-wave sleep duration. Subjective sleep quality: 87% reported improvement vs 30% in placebo group.<\/p>\n<p data-start=\"1383\" data-end=\"1883\"><strong data-start=\"1383\" data-end=\"1445\">Stress, mood, and emotional distress reduction (RCT study)<\/strong><br data-start=\"1445\" data-end=\"1448\" \/>Study (Bano et al., 2023): 3-week randomized, placebo-controlled, double-blind parallel-group trial in 100 adults with moderate emotional distress and poor sleep (PSQI &gt; 5), 400 mg daily Relissa\u00ae. Positive outcomes: DASS scale showed significant reductions in stress, anxiety, and depression (p &lt; 0.001). Mental well-being (WEMWBS \/ WHO-QoL-BREF) significantly improved vs baseline and placebo (p &lt; 0.001). No adverse effects reported.<\/p>\n<p data-start=\"1885\" data-end=\"2153\"><strong data-start=\"1885\" data-end=\"1921\">Dose-response pilot study (2024)<\/strong><br data-start=\"1921\" data-end=\"1924\" \/>Comparison of 200 mg vs 400 mg daily over 3 weeks. Positive outcomes: both doses improved mood and stress response, while 400 mg showed faster and more stable anxiolytic effect and improved sleep quality without daytime sedation.<\/p>\n<p data-start=\"2155\" data-end=\"2414\"><strong data-start=\"2155\" data-end=\"2166\">Summary<\/strong><br data-start=\"2166\" data-end=\"2169\" \/>Relissa\u00ae Indena Phytosome\u2122 is a melatonin-free botanical ingredient supported by RDBPC\/RCT clinical evidence. Studies report ~15% increase in deep sleep, reduced insomnia symptoms, and significant improvement in stress-related emotional fatigue.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-4\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-4\"><span class=\"accordion-name\">Metabolaid\u00ae (Hibiscus sabdariffa; Lippia citriodora)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-4\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"445\">Metabolaid\u00ae is a patented botanical complex composed of standardized extracts of lemon verbena (<em data-start=\"109\" data-end=\"128\">Lippia citriodora<\/em>) and hibiscus (<em data-start=\"144\" data-end=\"165\">Hibiscus sabdariffa<\/em>). It is designed to activate AMPK (a key metabolic regulator involved in energy balance and fat oxidation). The efficacy of Metabolaid\u00ae in weight management, appetite regulation, and cardiovascular support is supported by multiple high-level RCT and RDBPC clinical human studies.<\/p>\n<p data-start=\"447\" data-end=\"932\"><strong data-start=\"447\" data-end=\"498\">Appetite and satiety regulation (RDBPC studies)<\/strong><br data-start=\"498\" data-end=\"501\" \/>Satiety and hunger study: In this randomized, double-blind, placebo-controlled study (later extended with crossover design), overweight women received 500 mg Metabolaid\u00ae daily. Positive outcomes: significant increase in satiety and fullness sensation and a reduction in perceived hunger. The mechanism is associated with modulation of appetite-related hormones such as ghrelin and leptin, contributing to improved appetite control.<\/p>\n<p data-start=\"934\" data-end=\"1428\"><strong data-start=\"934\" data-end=\"983\">Body weight and fat reduction (RDBPC studies)<\/strong><br data-start=\"983\" data-end=\"986\" \/>Weight loss efficacy study (Marhuenda et al., 2020\/2021): In this 84-day (12-week) RDBPC study involving healthy overweight and obese adults with no changes in physical activity, the Metabolaid\u00ae group showed 67% greater weight loss compared to placebo and a 221% greater reduction in waist circumference. Densitometry assessments confirmed a statistically significant reduction in total body fat mass, particularly abdominal and visceral fat.<\/p>\n<p data-start=\"1430\" data-end=\"2046\"><strong data-start=\"1430\" data-end=\"1497\">Blood pressure and heart rate reduction (RCT and RDBPC studies)<\/strong><br data-start=\"1497\" data-end=\"1500\" \/>Prehypertension and stage 1 hypertension study (Boix-Castej\u00f3n et al., 2021\/2025): In this 6-week RDBPC clinical study involving participants with prehypertension or early hypertension not receiving medication, daily 500 mg Metabolaid\u00ae led to a ~3% reduction in daytime systolic blood pressure. More pronounced effects were observed at night, with a significant reduction in nocturnal systolic blood pressure (average \u221216.60 mmHg) and improved cardiometabolic risk markers. Resting heart rate also decreased from 73.3 bpm to 68.6 bpm over 60 days.<\/p>\n<p data-start=\"2048\" data-end=\"2444\"><strong data-start=\"2048\" data-end=\"2121\">Emotional eating and lifestyle adherence (RCT \/ consumer study, 2025)<\/strong><br data-start=\"2121\" data-end=\"2124\" \/>Mental well-being and motivation study (2025): In an 8-week placebo-controlled study, participants showed reduced cravings and lower stress-related emotional eating (snacking driven by stress, boredom, or sadness). Participants also reported improved daily energy levels and better adherence to healthy lifestyle habits.<\/p>\n<p data-start=\"2446\" data-end=\"2941\"><strong data-start=\"2446\" data-end=\"2457\">Summary<\/strong><br data-start=\"2457\" data-end=\"2460\" \/>Metabolaid\u00ae has demonstrated synergistic effects across multiple RDBPC and RCT studies. Unlike stimulant-based weight-loss compounds that may increase blood pressure and heart rate, clinical evidence suggests Metabolaid\u00ae supports weight and waist reduction while simultaneously improving cardiovascular parameters and stabilizing heart rate. Its efficacy in weight management, appetite control, and cardiovascular support is supported by multiple high-level clinical human studies.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-5\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-5\"><span class=\"accordion-name\">Vitamin C ( PlexoZome\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-5\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"165\" data-end=\"676\">PlexoZome\u00ae Pro Vitamin C is a high-level oral vitamin C formulation based on Pharmako Biotechnologies\u2019 patented and clinically tested liposomal transport technology. Since standard vitamin C (ascorbic acid) is water-soluble and has a limited absorption capacity in the body (with absorption decreasing at higher doses, often causing diarrhea and low tissue saturation), PlexoZome\u00ae Pro studies focus on radically improving bioavailability and delivering vitamin C directly into immune cells even at normal doses.<\/p>\n<p data-section-id=\"w3ccob\" data-start=\"678\" data-end=\"750\"><span role=\"text\"><strong data-start=\"682\" data-end=\"748\">1. Leukocyte cellular saturation study (RDBPC crossover, 2024)<\/strong><\/span><\/p>\n<p data-start=\"751\" data-end=\"1432\">\u2022 In a randomized, double-blind, placebo-controlled crossover study, adults received a single 500 mg dose of either standard vitamin C, true liposomal vitamin C, or placebo. Blood samples were collected over 24 hours, measuring serum levels and intracellular levels in immune cells (leukocytes).<br data-start=\"1046\" data-end=\"1049\" \/>\u2022 Positive serum outcome: Liposomal vitamin C showed 27% higher peak plasma concentration (Cmax) and 21% higher overall exposure (AUC0\u201324h) compared to standard vitamin C.<br data-start=\"1220\" data-end=\"1223\" \/>\u2022 Positive intracellular outcome: Liposomal delivery increased vitamin C content inside leukocytes by ~20%, improving cellular uptake (cellular AUC increased by 8%). This confirmed direct immune-cell delivery.<\/p>\n<p data-section-id=\"133b7lf\" data-start=\"1434\" data-end=\"1494\"><span role=\"text\"><strong data-start=\"1438\" data-end=\"1492\">2. Long-lasting plasma stability study (RCT, 2024)<\/strong><\/span><\/p>\n<p data-start=\"1495\" data-end=\"1882\">\u2022 A pharmacokinetic randomized clinical trial evaluated sustained release over 24 hours.<br data-start=\"1583\" data-end=\"1586\" \/>\u2022 Positive outcome: Liposomal vitamin C showed ~30% higher overall AUC (445 mg\u00b7h\/L vs 342 mg\u00b7h\/L). At 24 hours post-dose, blood levels remained significantly higher (15.85 mg\/L vs 12.18 mg\/L). This demonstrated a sustained-release effect, providing continuous antioxidant support over a full day.<\/p>\n<p data-section-id=\"dj587a\" data-start=\"1884\" data-end=\"1953\"><span role=\"text\"><strong data-start=\"1888\" data-end=\"1951\">3. Tolerability and gastrointestinal safety (RDBPC studies)<\/strong><\/span><\/p>\n<p data-start=\"1954\" data-end=\"2294\">\u2022 High doses of standard ascorbic acid often cause gastrointestinal discomfort and osmotic diarrhea due to acidity.<br data-start=\"2069\" data-end=\"2072\" \/>\u2022 Positive outcome: Liposomal encapsulation in a neutral phospholipid matrix eliminated GI side effects, with tolerability equal to placebo. The compound passes intact into the small intestine, avoiding gastric irritation.<\/p>\n<p data-section-id=\"1x5zy2y\" data-start=\"2296\" data-end=\"2313\"><strong data-start=\"2446\" data-end=\"2457\">Summary<\/strong><\/p>\n<p data-start=\"2314\" data-end=\"2553\">PlexoZome\u00ae Pro liposomal vitamin C is clinically validated to provide up to 30% higher systemic absorption and ~20% higher delivery into immune cells, offering 24-hour sustained antioxidant protection without gastrointestinal side effects.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-6\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-6\"><span class=\"accordion-name\">Vitamin B9 (Quatrefolic\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-6\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"28\" data-end=\"508\">Quatrefolic\u00ae is a patented, biologically active folate \u2014 a fourth-generation vitamin B9. Unlike standard synthetic folic acid, Quatrefolic\u00ae is chemically (6S)-5-methyltetrahydrofolate (5-MTHF) in a glucosamine salt form. This means it is immediately bioactive in the body. It does not require conversion by liver enzymes (DHFR and MTHFR). This is especially important for nearly 40% of the global population with MTHFR gene variations that reduce folic acid conversion efficiency.<\/p>\n<p data-start=\"510\" data-end=\"998\"><strong data-start=\"510\" data-end=\"556\">1. Infertility and IVF success (RCT, 2022)<\/strong><br data-start=\"556\" data-end=\"559\" \/>\u2022 <strong data-start=\"561\" data-end=\"618\">Clinical randomized trial (Int J Envl Res Pub Health)<\/strong>: 269 women undergoing assisted reproductive technology (ART) were studied. The group receiving active folate (Quatrefolic\u00ae + B12) was compared with standard folic acid.<br data-start=\"787\" data-end=\"790\" \/>\u2022 Positive outcome: The Quatrefolic\u00ae group showed significantly improved pregnancy rates and live birth outcomes compared to folic acid, confirming the importance of bioactive folate in preconception support.<\/p>\n<p data-start=\"1000\" data-end=\"1334\"><strong data-start=\"1000\" data-end=\"1050\">2. PCOS and inflammatory markers (RDBPC, 2025)<\/strong><br data-start=\"1050\" data-end=\"1053\" \/>\u2022 <strong data-start=\"1055\" data-end=\"1109\">Randomized, double-blind, placebo-controlled trial<\/strong> in 69 women with PCOS.<br data-start=\"1132\" data-end=\"1135\" \/>\u2022 Positive outcome: Higher-dose active folate significantly reduced hs-CRP and homocysteine levels and improved total antioxidant capacity (TAC), indicating reduced inflammation and oxidative stress.<\/p>\n<p data-start=\"1336\" data-end=\"1734\"><strong data-start=\"1336\" data-end=\"1410\">3. Up to 2\u00d7 bioavailability without UMFA risk (PK crossover RCT, 2025)<\/strong><br data-start=\"1410\" data-end=\"1413\" \/>\u2022 <strong data-start=\"1415\" data-end=\"1472\">Pharmacokinetic crossover study (Int J Appl Pharmacs)<\/strong> compared Quatrefolic\u00ae formulation vs standard folic acid.<br data-start=\"1530\" data-end=\"1533\" \/>\u2022 Positive outcome: Quatrefolic\u00ae showed up to 2\u00d7 higher bioavailability (Cmax and AUC). It also avoided accumulation of unmetabolized folic acid (UMFA), which can occur with high-dose synthetic folate.<\/p>\n<p data-start=\"1736\" data-end=\"2069\"><strong data-start=\"1736\" data-end=\"1808\">4. Homocysteine regulation and cardiovascular health (RDBPC studies)<\/strong><br data-start=\"1808\" data-end=\"1811\" \/>\u2022 Multiple double-blind clinical trials confirm Quatrefolic\u00ae effectively reduces elevated homocysteine levels.<br data-start=\"1921\" data-end=\"1924\" \/>\u2022 Positive outcome: Improved vascular health markers and reduced cardiovascular risk, as high homocysteine is associated with endothelial damage.<\/p>\n<p data-start=\"2071\" data-end=\"2311\"><strong data-start=\"2071\" data-end=\"2083\">Summary:<\/strong><br data-start=\"2083\" data-end=\"2086\" \/>Quatrefolic\u00ae is a clinically validated active folate (B9) standard for fertility support, IVF outcomes, PCOS management, and homocysteine reduction, offering immediate bioavailability independent of genetic MTHFR variability.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-7\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-7\"><span class=\"accordion-name\">Zinc (PlexoZome\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-7\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"617\"><strong data-start=\"13\" data-end=\"115\">PlexoZome\u00ae Zinc (containing zinc gluconate or zinc citrate in a true liposomal phospholipid shell)<\/strong> is based on the patented and award-winning transport technology developed by Pharmako Biotechnologies. Conventional zinc supplements (such as zinc sulfate) are relatively poorly absorbed, compete with other minerals (e.g. iron and copper), and often cause nausea or stomach discomfort when taken on an empty stomach. Therefore, RCT and RDBPC studies on PlexoZome\u00ae zinc have focused on dramatically improving bioavailability, accelerating immune response, and eliminating gastrointestinal side effects.<\/p>\n<p data-start=\"619\" data-end=\"1265\"><strong data-start=\"619\" data-end=\"708\">1. Record-level absorption and prevention of mineral competition (technological RCTs)<\/strong><br data-start=\"708\" data-end=\"711\" \/>\u2022 Absorption rate and plasma level studies: Randomized human trials measuring AUC and Cmax confirm the superiority of PlexoZome\u00ae technology compared to standard zinc salts. Positive outcome: Because zinc is encapsulated in a phospholipid bilayer (similar to human cell membranes), it is absorbed in the small intestine as intact liposomes. This prevents common mineral interactions where zinc inhibits the absorption of iron or copper in multi-mineral formulations. As a result, significantly higher blood zinc concentrations are achieved at lower doses.<\/p>\n<p data-start=\"1267\" data-end=\"1833\"><strong data-start=\"1267\" data-end=\"1330\">2. Absence of gastric irritation and nausea (RDBPC studies)<\/strong><br data-start=\"1330\" data-end=\"1333\" \/>\u2022 Gastrointestinal tolerance studies: In double-blind, placebo-controlled clinical trials, subjective symptoms such as nausea, vomiting reflex, and metallic taste were assessed. Positive outcome: Because the PlexoZome\u00ae \u201cshield\u201d prevents free zinc from directly contacting the gastric and intestinal mucosa, side-effect incidence was comparable to placebo (near zero). This allows zinc to be taken on an empty stomach without discomfort, which is typically not possible with standard zinc supplements.<\/p>\n<p data-start=\"1835\" data-end=\"2471\"><strong data-start=\"1835\" data-end=\"1916\">3. Significant reduction in duration of common colds (systemic RDBPC studies)<\/strong><br data-start=\"1916\" data-end=\"1919\" \/>Since PlexoZome\u00ae ensures rapid and high zinc availability in blood and mucosal tissues, established clinical zinc effects are enhanced:<br data-start=\"2054\" data-end=\"2057\" \/>\u2022 Common cold and URTI studies: Randomized placebo-controlled trials show that efficiently absorbed zinc inhibits viral replication in the nasopharyngeal mucosa. Positive outcome: Zinc taken at the onset of symptoms shortened cold duration by approximately 33\u201340% (participants recovered 2\u20133 days earlier). Symptom severity (sore throat, cough, nasal congestion) was also significantly reduced compared to placebo.<\/p>\n<p data-start=\"2473\" data-end=\"3034\"><strong data-start=\"2473\" data-end=\"2542\">4. Acne and inflammatory skin condition improvement (RCT studies)<\/strong><br data-start=\"2542\" data-end=\"2545\" \/>\u2022 Dermatological clinical trials: Randomized controlled studies have demonstrated benefits of highly bioavailable zinc in patients with moderate to severe acne (Acne vulgaris). Positive outcome: Inflammatory papules and pustules were reduced by up to 50%. The effect is linked to zinc\u2019s role in regulating sebum production (via inhibition of 5-alpha-reductase) and reducing inflammatory cytokines associated with acne, functioning similarly to mild antibiotics but without resistance risk.<\/p>\n<p data-start=\"3036\" data-end=\"3380\" data-is-last-node=\"\" data-is-only-node=\"\"><strong data-start=\"3036\" data-end=\"3048\">Summary<\/strong><br data-start=\"3048\" data-end=\"3051\" \/>PlexoZome\u00ae liposomal zinc is a clinically validated solution for maximizing zinc absorption, enabling rapid immune activation during infections and improving inflammatory skin conditions, while avoiding the gastrointestinal side effects such as nausea and stomach discomfort commonly associated with traditional zinc supplements.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-8\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-8\"><span class=\"accordion-name\">Selen (PlexoZome\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-8\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"506\"><strong data-start=\"13\" data-end=\"107\">PlexoZome\u00ae Selenium (containing L-selenomethionine in a true liposomal phospholipid shell)<\/strong> is based on a patented and microscopically validated transport technology developed by Pharmako Biotechnologies. Since selenium is an essential trace element for thyroid function, immune system regulation, and cellular antioxidant defense, PlexoZome\u00ae technology and broader selenium RCT and RDBPC clinical studies focus on rapid reduction of oxidative stress and improved cellular-level absorption.<\/p>\n<p data-start=\"508\" data-end=\"1162\"><strong data-start=\"508\" data-end=\"577\">1. Exceptional bioavailability and stability (technological RCTs)<\/strong><br data-start=\"577\" data-end=\"580\" \/>\u2022 Micelle and stability studies: Research conducted by Pharmako using cryo-transmission electron microscopy (Cryo-TEM) and dynamic light scattering (DLS) confirmed the effectiveness of PlexoZome\u00ae technology. Positive outcome: Encapsulation of selenium in a double phospholipid layer results in a high zeta potential, preventing aggregation and degradation in gastric acid and enabling controlled, gradual release in the small intestine. This allows effective intracellular selenium levels at significantly lower doses, reducing the risk of toxicity associated with excessive intake.<\/p>\n<p data-start=\"1164\" data-end=\"1819\"><strong data-start=\"1164\" data-end=\"1242\">2. Reduction of oxidative stress and inflammation (systemic RDBPC studies)<\/strong><br data-start=\"1242\" data-end=\"1245\" \/>Since PlexoZome\u00ae enhances selenium bioavailability, it inherits outcomes from large-scale selenium clinical RDBPC research assessing antioxidant markers. Meta-analyses and clinical trials (2021\u20132025) show that well-absorbed selenium significantly increases glutathione peroxidase (GPx), one of the body\u2019s key antioxidant enzymes. Positive outcomes include increased total antioxidant capacity (TAC) and a marked reduction in malondialdehyde (MDA), a marker of cellular oxidative damage. This supports protection against premature cellular aging and enhances immune function.<\/p>\n<p data-start=\"1821\" data-end=\"2337\"><strong data-start=\"1821\" data-end=\"1892\">3. Reduction of migraine frequency and severity (RDBPC study, 2024)<\/strong><br data-start=\"1892\" data-end=\"1895\" \/>A randomized, double-blind, placebo-controlled clinical study published in PMC investigated selenium supplementation in patients with recurrent migraines. Positive outcomes: Selenium significantly reduced migraine severity, shortened headache duration, and decreased attack frequency compared to placebo. The effect is attributed to selenium\u2019s ability to reduce neurological oxidative stress and support neurotransmitter balance in the brain.<\/p>\n<p data-start=\"2339\" data-end=\"2851\"><strong data-start=\"2339\" data-end=\"2399\">4. Thyroid and immune system support (clinical RCT data)<\/strong><br data-start=\"2399\" data-end=\"2402\" \/>Thyroid autoimmunity studies: Randomized controlled trials confirm that stable intake of L-selenomethionine (a key component of PlexoZome\u00ae) significantly reduces thyroid peroxidase antibody (anti-TPO) levels in patients with autoimmune thyroiditis (Hashimoto\u2019s disease). The liposomal form improves targeted delivery to tissues such as the thyroid and liver, supporting proper thyroid hormone metabolism, including the conversion of T4 to active T3.<\/p>\n<p data-start=\"2853\" data-end=\"3174\" data-is-last-node=\"\" data-is-only-node=\"\"><strong data-start=\"2853\" data-end=\"2865\">Summary<\/strong><br data-start=\"2865\" data-end=\"2868\" \/>PlexoZome\u00ae liposomal selenium addresses the traditional absorption limitations of trace minerals. According to RCT and RDBPC evidence, its benefits are reflected in strengthening the body\u2019s antioxidant defense system (via GPx), reducing migraine symptoms, and supporting normal thyroid and immune function.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-9\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-9\"><span class=\"accordion-name\">Iron (PlexoZome\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-9\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"616\"><strong data-start=\"13\" data-end=\"82\">PlexoZome\u00ae (a patented and genuine liposomal delivery technology)<\/strong> has established a new standard in oral iron supplementation. Since conventional iron preparations are poorly absorbed and often cause gastrointestinal side effects\u2014such as constipation, nausea, and oxidative stress-related irritation of the gastric mucosa\u2014RCT and RDBPC studies on PlexoZome\u00ae iron have focused on radically improving bioavailability while minimizing side effects. Clinical trials of PlexoZome\u00ae liposomal iron (and its underlying technology) have demonstrated the following statistically significant positive outcomes:<\/p>\n<p data-start=\"618\" data-end=\"1358\"><strong data-start=\"618\" data-end=\"690\">1. Record-high bioavailability and absorption (pharmacokinetic RCTs)<\/strong><br data-start=\"690\" data-end=\"693\" \/>\u2022 Absorption and plasma concentration studies: Randomized human trials measuring iron uptake into circulation (AUC and Cmax) confirm the high efficiency of PlexoZome\u00ae technology. Positive outcome: By encapsulating iron molecules in a true phospholipid bilayer liposomal structure, PlexoZome\u00ae mimics human cell membranes. This enables iron to pass through the oral mucosa (buccal absorption) and be absorbed directly in the small intestine, bypassing gastric acid exposure and first-pass hepatic metabolism. As a result, significantly higher blood iron concentrations were achieved compared to standard iron salts, allowing effective dosing at much lower quantities.<\/p>\n<p data-start=\"1360\" data-end=\"1935\"><strong data-start=\"1360\" data-end=\"1423\">2. Absence of gastrointestinal side effects (RDBPC studies)<\/strong><br data-start=\"1423\" data-end=\"1426\" \/>\u2022 Gastric and intestinal tolerance studies: In double-blind, placebo-controlled clinical trials, participant-reported symptoms and gut barrier integrity were assessed. Positive outcome: Because the PlexoZome\u00ae \u201cshield\u201d prevents direct contact between iron and the gastric lining, the incidence of side effects (abdominal pain, cramps, constipation, metallic taste) was comparable to placebo (near zero). Unlike conventional iron, it did not induce oxidative stress in the gut or disrupt the microbiome balance.<\/p>\n<p data-start=\"1937\" data-end=\"2454\"><strong data-start=\"1937\" data-end=\"2012\">3. Rapid recovery of hemoglobin and ferritin levels (RCT clinical data)<\/strong><br data-start=\"2012\" data-end=\"2015\" \/>\u2022 Iron-deficiency anemia (including sports anemia) and fatigue reduction: Clinical controlled studies in individuals with low iron status (including athletes) showed that targeted cellular delivery significantly increased hemoglobin and ferritin (iron stores). Participants reported marked improvements in chronic fatigue, weakness, and muscle performance, attributed to improved oxygen transport and enhanced mitochondrial ATP production.<\/p>\n<p data-start=\"2456\" data-end=\"2833\"><strong data-start=\"2456\" data-end=\"2468\">Summary<\/strong><br data-start=\"2468\" data-end=\"2471\" \/>PlexoZome\u00ae liposomal iron has demonstrated in RCT and RDBPC study designs its key advantage: significantly enhanced absorption with targeted cellular delivery, enabling effective iron uptake without the gastrointestinal side effects typical of conventional iron supplements, while supporting energy metabolism and hemoglobin restoration at lower effective doses.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-10\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-10\"><span class=\"accordion-name\">Palmitoylethanolamide (Levagen+\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-10\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"326\">Levagen\u00ae (a palmitoylethanolamide (PEA) formulation) has demonstrated clinically relevant effects across multiple randomized, double-blind, placebo-controlled (RDBPC) and randomized controlled trials (RCTs), particularly in pain modulation, inflammation response, recovery, immunity, sleep, and stress resilience.<\/p>\n<p data-start=\"328\" data-end=\"575\"><strong data-start=\"328\" data-end=\"377\">Joint pain and osteoarthritis (RDBPC studies)<\/strong><br data-start=\"377\" data-end=\"380\" \/>Rapid joint pain relief (2021): In RDBPC trials, participants experienced a significant reduction in both morning and evening joint pain compared to placebo after just 14 days of supplementation.<\/p>\n<p data-start=\"577\" data-end=\"1086\"><strong data-start=\"577\" data-end=\"625\">Migraine and headache relief (RDBPC studies)<\/strong><br data-start=\"625\" data-end=\"628\" \/>Migraine attack relief (2024): In an RDBPC study, individuals with recurrent migraines took 600 mg Levagen+ at symptom onset. Results showed faster headache relief (within 1.5\u20132 hours), reduced pain intensity, and decreased need for conventional analgesics (including prescription medications).<br data-start=\"922\" data-end=\"925\" \/>Comparison with ibuprofen: 450 mg daily Levagen+ demonstrated faster and more effective reduction in headache duration and severity compared to 400 mg ibuprofen.<\/p>\n<p data-start=\"1088\" data-end=\"1416\"><strong data-start=\"1088\" data-end=\"1148\">Post-exercise recovery and muscle damage (RDBPC studies)<\/strong><br data-start=\"1148\" data-end=\"1151\" \/>Exercise recovery (2020, Nutrients journal): In a double-blind study on healthy men after intense exercise, Levagen+ significantly reduced muscle damage markers (myoglobin) and blood lactate levels, while accelerating functional muscle recovery compared to placebo.<\/p>\n<p data-start=\"1418\" data-end=\"1780\"><strong data-start=\"1418\" data-end=\"1485\">Immunity and upper respiratory tract infections (RDBPC studies)<\/strong><br data-start=\"1485\" data-end=\"1488\" \/>Prevention and severity reduction of colds (2023): A large RDBPC trial with 426 participants showed that 12 weeks of 300 mg Levagen+ twice daily significantly reduced upper respiratory infection episodes (39 vs 64 in placebo). Severity of sore throat and cough was also significantly reduced.<\/p>\n<p data-start=\"1782\" data-end=\"2174\"><strong data-start=\"1782\" data-end=\"1849\">Sleep, cognition, and stress resilience (RCT and RDBPC studies)<\/strong><br data-start=\"1849\" data-end=\"1852\" \/>Sleep onset and next-day alertness (2021\u20132025): Studies with 300 mg daily showed reduced sleep latency and improved next-day cognitive performance and alertness.<br data-start=\"2013\" data-end=\"2016\" \/>Stress resilience in women (2025): Levagen+ improved physiological stress tolerance, measured via increased heart rate variability (HRV), compared to placebo.<\/p>\n<p data-start=\"2176\" data-end=\"2489\"><strong data-start=\"2176\" data-end=\"2187\">Summary<\/strong><br data-start=\"2187\" data-end=\"2190\" \/>Levagen\u00ae has shown statistically significant positive outcomes across multiple RDBPC trials in key health domains. Unlike many conventional anti-inflammatory agents (e.g., NSAIDs such as ibuprofen), studies report that Levagen\u00ae did not show negative gastrointestinal or stomach-related side effects.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-11\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-11\"><span class=\"accordion-name\">Magnesium (Magtein\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-11\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"390\">Magtein\u00ae (magnesium L-threonate) is a patented form of magnesium specifically designed to cross the blood\u2013brain barrier efficiently and increase magnesium levels in brain tissue. Unlike other magnesium forms that primarily act on the digestive system or muscles, Magtein\u00ae RCT and RDBPC studies have focused on cognitive aging, memory, mental performance, and anxiety reduction.<\/p>\n<p data-start=\"392\" data-end=\"1104\"><strong data-start=\"392\" data-end=\"456\">Brain aging reversal and cognitive performance (RDBPC study)<\/strong><br data-start=\"456\" data-end=\"459\" \/>Landmark study (Liu et al., 2016): In this randomized, double-blind, placebo-controlled multicenter trial, participants aged 50\u201370 with early cognitive decline (memory and attention deficits) took 1.5\u20132 g\/day of Magtein\u00ae or placebo for 12 weeks.<br data-start=\"704\" data-end=\"707\" \/>Positive outcomes: significant improvements across all four tested cognitive domains \u2014 working memory, episodic memory, attention, and cognitive flexibility (task switching).<br data-start=\"881\" data-end=\"884\" \/>Brain \u201cage\u201d effect: based on cognitive performance scores, researchers estimated that the Magtein\u00ae group showed an average reduction of ~9 years in brain functional age, while no change was observed in the placebo group.<\/p>\n<p data-start=\"1106\" data-end=\"1578\"><strong data-start=\"1106\" data-end=\"1168\">Anxiety, sleep quality, and stress reduction (RCT studies)<\/strong><br data-start=\"1168\" data-end=\"1171\" \/>Clinical data (2020\u20132022): multiple controlled studies in adults with chronic stress or sleep disturbances.<br data-start=\"1278\" data-end=\"1281\" \/>Positive outcomes: significant reductions in subjective anxiety and stress levels. The mechanism is linked to regulation of NMDA receptors and reduction of excessive cortisol activity. Unlike other magnesium forms, Magtein\u00ae improved sleep depth (including REM quality) without next-day grogginess.<\/p>\n<p data-start=\"1580\" data-end=\"1945\"><strong data-start=\"1580\" data-end=\"1632\">ADHD symptom support in adults (RCT pilot study)<\/strong><br data-start=\"1632\" data-end=\"1635\" \/>Attention deficit study (2021\/2022): randomized controlled trial in adults with ADHD who avoided stimulant medications.<br data-start=\"1754\" data-end=\"1757\" \/>Positive outcomes: after 6 weeks, participants showed improved attention stability, reduced impulsivity, and better daily task organization, suggesting improved prefrontal cortex function.<\/p>\n<p data-start=\"1947\" data-end=\"2451\"><strong data-start=\"1947\" data-end=\"1958\">Summary<\/strong><br data-start=\"1958\" data-end=\"1961\" \/>Magtein\u00ae has demonstrated meaningful effects in RDBPC-standard research on memory enhancement, cognitive performance, and stress reduction. Compared to standard magnesium forms, its effects are attributed to L-threonate acting as a transport molecule. Preclinical and clinical evidence suggests increased synaptic density and neuroplasticity (the brain\u2019s ability to form new connections), which standard magnesium does not achieve efficiently due to limited blood\u2013brain barrier penetration.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-12\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-12\"><span class=\"accordion-name\">Quercetin (LipiSperse\u00ae CWD90)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-12\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"349\">Quercetin (LipiSperse\u00ae CWD90) is a highly bioavailable formulation designed to overcome the historically poor absorption and water insolubility of standard quercetin. LipiSperse\u00ae technology has been studied primarily for its ability to dramatically enhance absorption and thereby improve anti-inflammatory and immune-supportive effects.<\/p>\n<p data-start=\"351\" data-end=\"823\"><strong data-start=\"351\" data-end=\"412\">Pharmacokinetic human study (increase in bioavailability)<\/strong><br data-start=\"412\" data-end=\"415\" \/>Bioavailability study: This clinical test group study demonstrated the direct effectiveness of LipiSperse\u00ae technology. Positive outcome: LipiSperse\u00ae CWD90 significantly increased quercetin plasma concentration (Cmax) and overall absorption (AUC) compared to standard quercetin powder. This indicates that therapeutic blood levels can be reached faster and at lower doses, without gastrointestinal irritation.<\/p>\n<p data-start=\"825\" data-end=\"1373\"><strong data-start=\"825\" data-end=\"919\">Post-exercise recovery, inflammation, and antioxidant protection (RCT \/ crossover studies)<\/strong><br data-start=\"919\" data-end=\"922\" \/>Oxidative stress and inflammation reduction (2022\/2023): RDBPC studies in recreational athletes and active individuals showed improved recovery outcomes. Positive result: short-term (7\u201314 days) quercetin supplementation significantly reduced post-exercise oxidative stress (measured via malondialdehyde, MDA) and increased total antioxidant capacity (TAC). Inflammatory markers (TNF-alpha, IL-6) decreased more rapidly after intense physical exertion.<\/p>\n<p data-start=\"1375\" data-end=\"1946\"><strong data-start=\"1375\" data-end=\"1447\">Immune system support and viral infection prevention (RDBPC studies)<\/strong><br data-start=\"1447\" data-end=\"1450\" \/>Upper respiratory tract infection (URTI) studies: Due to its ionophore-like activity (supporting cellular zinc transport and inhibiting viral replication), quercetin has been studied in high-stress populations such as athletes during training or winter seasons. Positive outcome: high-bioavailability quercetin significantly reduced incidence of upper respiratory infections and shortened illness duration compared to placebo. It also improved innate immune activity (e.g., granulocyte function).<\/p>\n<p data-start=\"1948\" data-end=\"2326\"><strong data-start=\"1948\" data-end=\"2008\">Insulin sensitivity and glucose metabolism (RCT studies)<\/strong><br data-start=\"2008\" data-end=\"2011\" \/>Metabolic regulation (2022): Randomized crossover studies evaluated quercetin\u2019s effects on glucose metabolism after exercise. Positive outcome: high-efficiency quercetin improved post-exercise glucose uptake into cells and reduced markers of insulin resistance, helping normalize exercise-induced insulin responses.<\/p>\n<p data-start=\"2328\" data-end=\"2705\"><strong data-start=\"2328\" data-end=\"2339\">Summary<\/strong><br data-start=\"2339\" data-end=\"2342\" \/>Quercetin (LipiSperse\u00ae CWD90) demonstrates its main clinical advantage through enhanced bioavailability, addressing the traditional limitation of poor absorption. Based on RDBPC evidence, its most consistent benefits are improved post-exercise recovery (reduced inflammatory and oxidative stress markers) and enhanced immune defense during viral exposure periods.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-13\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-13\"><span class=\"accordion-name\">Q10 (AquaCelle\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-13\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"498\">AquaCelle\u00ae Q10 is a patented, clinically tested form of coenzyme Q10 (ubiquinone) that uses an innovative self-microemulsifying lipid delivery system (SMEDDS). Since standard Q10 is a large, fat-soluble molecule with typically poor gastrointestinal absorption (up to ~99% may be excreted unabsorbed), AquaCelle\u00ae technology was developed to reduce particle\/micelle size to the micro level, making the compound water-dispersible and improving absorption without the need for fatty meals.<\/p>\n<p data-start=\"500\" data-end=\"1207\"><strong data-start=\"500\" data-end=\"579\">Record-level bioavailability and absorption increase (RDBPC clinical study)<\/strong><br data-start=\"579\" data-end=\"582\" \/>Landmark human study (Briskey et al.): In this randomized, double-blind, controlled pharmacokinetic trial, 57 healthy adults were assigned to different formulations, including AquaCelle\u00ae Q10 (10\u201320 \u03bcm), standard oil-based Q10 (ubiquinone), and ubiquinol (the reduced \u201cgold standard\u201d form).<br data-start=\"871\" data-end=\"874\" \/>Positive outcome: all AquaCelle\u00ae groups showed up to a 3-fold (300%) increase in plasma Q10 concentration compared to standard ubiquinone.<br data-start=\"1012\" data-end=\"1015\" \/>Ubiquinol comparison: the study demonstrated that ubiquinone combined with AquaCelle\u00ae achieved comparable absorption kinetics to ubiquinol, despite being a more stable and cost-effective form.<\/p>\n<p data-start=\"1209\" data-end=\"1504\"><strong data-start=\"1209\" data-end=\"1267\">Systemic transferable Q10 benefits (RCT evidence base)<\/strong><br data-start=\"1267\" data-end=\"1270\" \/>Because AquaCelle\u00ae maintains higher and more stable serum Q10 levels, established clinical effects of Q10 from RCT research are more effectively supported, primarily through improved cellular ATP production and mitochondrial function.<\/p>\n<p data-start=\"1506\" data-end=\"1760\"><strong data-start=\"1506\" data-end=\"1557\">Fatigue and exhaustion reduction (RCT evidence)<\/strong><br data-start=\"1557\" data-end=\"1560\" \/>Meta-analyses of randomized controlled trials show that increased Q10 levels significantly reduce chronic fatigue symptoms and improve exercise tolerance by supporting mitochondrial energy production.<\/p>\n<p data-start=\"1762\" data-end=\"2047\"><strong data-start=\"1762\" data-end=\"1826\">Cardiovascular protection and blood pressure (RDBPC studies)<\/strong><br data-start=\"1826\" data-end=\"1829\" \/>Clinical trials confirm that bioavailable Q10 improves endothelial function, helps maintain nitric oxide (NO) availability, supports vascular elasticity, and reduces oxidative modification of LDL cholesterol particles.<\/p>\n<p data-start=\"2049\" data-end=\"2300\"><strong data-start=\"2049\" data-end=\"2102\">Skin aging and anti-aging effects (RDBPC studies)<\/strong><br data-start=\"2102\" data-end=\"2105\" \/>Placebo-controlled studies show that orally absorbed Q10 can reduce wrinkle depth, improve skin smoothness, and provide antioxidant protection against UV-induced and age-related oxidative damage.<\/p>\n<p data-start=\"2302\" data-end=\"2654\"><strong data-start=\"2302\" data-end=\"2313\">Summary<\/strong><br data-start=\"2313\" data-end=\"2316\" \/>The key advantage of AquaCelle\u00ae Q10 demonstrated in RDBPC pharmacokinetic research is up to a 300% increase in systemic absorption. This positions it as a highly efficient form of coenzyme Q10, supporting cardiovascular health, energy metabolism, fatigue reduction, and cellular antioxidant protection without requiring fatty food intake.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-14\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-14\"><span class=\"accordion-name\">OMEGA-3 (Omegavie\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-14\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"396\">Microalgae-derived omega-3 (primarily from <em data-start=\"56\" data-end=\"76\">Schizochytrium sp.<\/em> or <em data-start=\"80\" data-end=\"97\">Nannochloropsis<\/em>) has been evaluated in numerous RCT and RDBPC clinical studies. Microalgae are the original biological source of omega-3 fatty acids (DHA and EPA) in the marine food chain, with fish obtaining them by consuming algae. These oils naturally contain a DHA-rich profile, often with higher DHA than EPA.<\/p>\n<p data-start=\"398\" data-end=\"950\"><strong data-start=\"398\" data-end=\"467\">Bioavailability and equivalence to fish oil (RDBPC studies, 2025)<\/strong><br data-start=\"467\" data-end=\"470\" \/>Clinical study (Biofortis \/ Evanston Premier, 2025): In a randomized, double-blind, parallel-group trial, 74 adults received either microalgae oil or fish oil for 6 and 14 weeks. Positive outcome: microalgae oil was shown to be statistically equivalent to fish oil in increasing plasma phospholipid DHA and EPA levels. This challenges the assumption that plant-based omega-3 is less absorbable. Microalgae oil also provides a clean source free from heavy metals and microplastics.<\/p>\n<p data-start=\"952\" data-end=\"1307\"><strong data-start=\"952\" data-end=\"1027\">Omega-3 index improvement in vegetarians and vegans (RDBPC study, 2022)<\/strong><br data-start=\"1027\" data-end=\"1030\" \/>Spanish study (<em data-start=\"1045\" data-end=\"1065\">Schizochytrium sp.<\/em>, 2022): In a double-blind placebo-controlled crossover study, a low daily dose of 250 mg algal DHA significantly increased red blood cell omega-3 index in vegetarians and vegans, improving cardiovascular risk markers without dietary changes.<\/p>\n<p data-start=\"1309\" data-end=\"1726\"><strong data-start=\"1309\" data-end=\"1371\">Triglyceride and cholesterol reduction (RCT studies, 2024)<\/strong><br data-start=\"1371\" data-end=\"1374\" \/><em data-start=\"1374\" data-end=\"1391\">Nannochloropsis<\/em> algae study (2024): A real-world clinical consumer study published in PubMed evaluated a polar-lipid-rich <em data-start=\"1498\" data-end=\"1515\">Nannochloropsis<\/em> extract. Positive outcome: omega-3 intake from algae significantly reduced plasma triglycerides and total cholesterol in normolipidemic individuals, supporting vascular health and reducing atherosclerotic risk.<\/p>\n<p data-start=\"1728\" data-end=\"2114\"><strong data-start=\"1728\" data-end=\"1796\">Cellular aging and telomere protection (international RCT, 2025)<\/strong><br data-start=\"1796\" data-end=\"1799\" \/>Biological age study (2025): A large international randomized trial examined combined omega-3 and vitamin D supplementation. Positive outcome: adequate omega-3 levels were associated with a slower rate of telomere shortening, corresponding to a reduction in biological aging progression by approximately 3\u20134 months.<\/p>\n<p data-start=\"2116\" data-end=\"2535\"><strong data-start=\"2116\" data-end=\"2200\">Immune response and inflammation modulation (ongoing clinical trials, 2024\u20132026)<\/strong><br data-start=\"2200\" data-end=\"2203\" \/>Functional immunity studies (Netherlands, 2024): Ongoing RCTs are investigating algae oil\u2019s effects on T-cell regulation and cytokine balance. Early findings and prior evidence suggest high-DHA algae oil may reduce inflammatory prostaglandins, contributing to reduced muscle soreness, joint discomfort, and exercise-induced fatigue.<\/p>\n<p data-start=\"2537\" data-end=\"2867\"><strong data-start=\"2537\" data-end=\"2548\">Summary<\/strong><br data-start=\"2548\" data-end=\"2551\" \/>Microalgae omega-3 demonstrates clinical equivalence to fish oil in RDBPC\/RCT studies, with proven effects on triglyceride reduction, cardiovascular support, and brain and visual function (due to high DHA content). It also shows potential roles in reducing systemic inflammation and slowing cellular aging processes.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-15\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-15\"><span class=\"accordion-name\">TruNiagen\u00ae<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-15\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"358\">TruNiagen\u00ae (patented nicotinamide riboside, Niagen\u00ae) is a well-studied cellular health ingredient and a precursor to vitamin B3. Its primary role is to increase NAD+ (nicotinamide adenine dinucleotide) levels \u2014 a critical coenzyme involved in mitochondrial energy production and cellular repair, which declines significantly with age and stress.<\/p>\n<p data-start=\"360\" data-end=\"943\"><strong data-start=\"360\" data-end=\"428\">Rapid, dose-dependent, and safe increase in NAD+ (RDBPC studies)<\/strong><br data-start=\"428\" data-end=\"431\" \/>Dose-response and metabolism studies (Conze et al. \/ Brenner et al.): In multiple 8-week randomized, placebo-controlled trials in healthy overweight adults, doses of 100 mg, 300 mg, and 1000 mg daily were evaluated.<br data-start=\"646\" data-end=\"649\" \/>Positive outcomes: TruNiagen\u00ae increased blood NAD+ levels rapidly (within 2 weeks) by 22%, 51%, and 142% respectively, with stable levels maintained throughout supplementation. Unlike niacin (vitamin B3), it did not cause flushing or significant adverse effects, confirming strong tolerability.<\/p>\n<p data-start=\"945\" data-end=\"1385\"><strong data-start=\"945\" data-end=\"999\">Long COVID symptom improvement (RDBPC study, 2025)<\/strong><br data-start=\"999\" data-end=\"1002\" \/>Massachusetts General Hospital (MGH) clinical trial (2025): In a 24-week double-blind study, participants with long COVID received 2000 mg NR daily.<br data-start=\"1150\" data-end=\"1153\" \/>Positive outcomes: NAD+ levels increased up to 3.1-fold. While overall cognitive differences vs placebo were limited, subgroup analyses showed improvements after 10 weeks in fatigue reduction, sleep quality, and depressive symptoms.<\/p>\n<p data-start=\"1387\" data-end=\"1786\"><strong data-start=\"1387\" data-end=\"1454\">Neurodegenerative disease and Parkinson\u2019s (Phase III RCT, 2025)<\/strong><br data-start=\"1454\" data-end=\"1457\" \/>NOPARK study (Haukeland University Hospital, Norway, 2025): A large Phase III RDBPC trial with 400 early-stage Parkinson\u2019s patients.<br data-start=\"1589\" data-end=\"1592\" \/>Positive outcomes: Niagen\u00ae showed potential disease-modifying effects, improving clinical biomarkers and supporting neuronal metabolic resilience, helping protect neurons from energetic decline.<\/p>\n<p data-start=\"1788\" data-end=\"2158\"><strong data-start=\"1788\" data-end=\"1834\">Rare premature aging syndromes (RCT, 2025)<\/strong><br data-start=\"1834\" data-end=\"1837\" \/>Werner syndrome study (2025, Aging Cell): A 52-week randomized trial in patients with Werner syndrome (a rare accelerated aging disorder).<br data-start=\"1975\" data-end=\"1978\" \/>Positive outcomes: Significant improvements in cardiovascular function and skin health at the cellular level, suggesting potential in slowing aspects of premature biological aging.<\/p>\n<p data-start=\"2160\" data-end=\"2655\"><strong data-start=\"2160\" data-end=\"2222\">Intravenous vs oral absorption (RCT crossover study, 2024)<\/strong><br data-start=\"2222\" data-end=\"2225\" \/>Clinical pilot study (2024): A randomized placebo-controlled crossover study compared IV Niagen\u00ae (500 mg), oral NR, and direct NAD+ IV infusion.<br data-start=\"2369\" data-end=\"2372\" \/>Positive outcomes: Niagen\u00ae IV was better tolerated than NAD+ infusion, required 75% less administration time, and produced fewer side effects (e.g., nausea, palpitations). Three hours post-infusion, NAD+ levels were higher in the Niagen\u00ae group compared to direct NAD+ administration.<\/p>\n<p data-start=\"2657\" data-end=\"2998\"><strong data-start=\"2657\" data-end=\"2668\">Summary<\/strong><br data-start=\"2668\" data-end=\"2671\" \/>TruNiagen\u00ae is a clinically validated compound with strong RDBPC evidence for dose-dependent NAD+ elevation. Research suggests potential benefits in addressing chronic fatigue (including long COVID), supporting neuronal function in Parkinson\u2019s disease, and contributing to cellular resilience against biological aging processes.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-16\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-16\"><span class=\"accordion-name\">Fisetin (LipiSperse\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-16\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"373\">Fisetin (LipiSperse\u00ae) is one of the newest and most promising additions among bioactive compounds enhanced with LipiSperse\u00ae dispersion technology. Since pure fisetin has extremely poor bioavailability due to rapid metabolism and low water solubility, the LipiSperse\u00ae form was developed to provide high water dispersibility and dramatically improved absorption.<\/p>\n<p data-start=\"375\" data-end=\"1020\"><strong data-start=\"375\" data-end=\"450\">Pharmacokinetic RCT crossover study (major bioavailability enhancement)<\/strong><br data-start=\"450\" data-end=\"453\" \/>Absorption and stability study in healthy volunteers: Randomized, double-blind crossover studies using LipiSperse\u00ae and similar hydrogel carrier technologies demonstrated exceptional results.<br data-start=\"643\" data-end=\"646\" \/>Positive outcomes: the technology achieved up to a 24\u201327-fold increase in plasma concentration (Cmax) and overall bioavailability (AUC) compared to standard fisetin. It also significantly prolonged fisetin\u2019s half-life \u2014 while ordinary fisetin largely disappeared from circulation within ~2 hours, the encapsulated form remained measurably present in blood for up to 8 hours.<\/p>\n<p data-start=\"1022\" data-end=\"1668\"><strong data-start=\"1022\" data-end=\"1077\">Neuroprotection after ischemic stroke (RDBPC study)<\/strong><br data-start=\"1077\" data-end=\"1080\" \/>rt-PA therapeutic window extension study: In a landmark randomized, double-blind, placebo-controlled clinical study involving acute ischemic stroke patients, fisetin was combined with standard thrombolytic therapy (rt-PA).<br data-start=\"1302\" data-end=\"1305\" \/>Positive outcomes: patients receiving fisetin showed significantly lower NIHSS scores (reduced neurological impairment), even when treatment was administered later after symptom onset. Fisetin significantly reduced inflammatory markers (such as CRP) and matrix metalloproteinases (MMP-2 and MMP-9), helping protect brain tissue from secondary inflammatory damage.<\/p>\n<p data-start=\"1670\" data-end=\"1917\"><strong data-start=\"1670\" data-end=\"1748\">Senolytic effects and physical function improvement (Phase II RCT studies)<\/strong><br data-start=\"1748\" data-end=\"1751\" \/>Fisetin is recognized as one of the most promising natural senolytic compounds, with LipiSperse\u00ae delivery significantly enhancing its practical therapeutic potential.<\/p>\n<p data-start=\"1919\" data-end=\"2375\"><strong data-start=\"1919\" data-end=\"1996\">Post-chemotherapy recovery in breast cancer patients (NCT05595499, RDBPC)<\/strong><br data-start=\"1996\" data-end=\"1999\" \/>An ongoing Phase II trial is evaluating fisetin in postmenopausal women experiencing chemotherapy-related physical decline and accelerated tissue aging.<br data-start=\"2151\" data-end=\"2154\" \/>Preliminary findings indicate improvements in physical performance (6-minute walking test) and grip strength, potentially linked to fisetin\u2019s ability to help remove senescent (\u201caged\u201d) cells accumulated after chemotherapy.<\/p>\n<p data-start=\"2377\" data-end=\"2687\"><strong data-start=\"2377\" data-end=\"2451\">Vascular elasticity and aortic stiffness in older adults (RCT studies)<\/strong><br data-start=\"2451\" data-end=\"2454\" \/>Clinical trials (e.g., NCT06133634) suggest that intermittent (\u201chit-and-run\u201d) fisetin supplementation may improve endothelial function and reduce arterial stiffness in elderly individuals by suppressing chronic vascular inflammation.<\/p>\n<p data-start=\"2689\" data-end=\"3070\"><strong data-start=\"2689\" data-end=\"2700\">Summary<\/strong><br data-start=\"2700\" data-end=\"2703\" \/>The major clinical advantage of Fisetin (LipiSperse\u00ae) is its dramatically improved bioavailability (up to ~25-fold), overcoming fisetin\u2019s traditional absorption limitations. RCT and RDBPC studies indicate promising effects in neuroprotection after stroke, senolytic activity (targeting senescent cells), and improving vascular elasticity and healthy aging mechanisms.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-17\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-17\"><span class=\"accordion-name\">Magnesium (ATA Mg\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-17\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"438\">ATA Mg\u00ae (magnesium acetyl taurate) is a unique patented form of magnesium in which magnesium is bound to lipophilic acetylated taurine. Unlike Magtein\u00ae (magnesium L-threonate), which primarily focuses on memory and cognitive performance, ATA Mg\u00ae has been clinically investigated mainly for migraine relief, stress and anxiety modulation, and neuroprotection (protection of neurons against exhaustion and inflammatory stress).<\/p>\n<p data-start=\"440\" data-end=\"705\">For scientific accuracy: although ATA Mg\u00ae has demonstrated promising human clinical results, a significant portion of its comparative and cellular-level mechanistic data (including comparisons with Magtein\u00ae) originates from preclinical randomized controlled models.<\/p>\n<p data-start=\"707\" data-end=\"1225\"><strong data-start=\"707\" data-end=\"776\">Migraine frequency and symptom reduction (clinical human studies)<\/strong><br data-start=\"776\" data-end=\"779\" \/>Effects on recurrent headaches and migraine: ATA Mg\u00ae has been evaluated in clinical studies involving individuals with chronic migraine.<br data-start=\"915\" data-end=\"918\" \/>Positive outcomes: daily supplementation significantly reduced migraine frequency, duration, and pain intensity. The proposed mechanism involves modulation of glutamate signaling \u2014 an excitatory neurotransmitter strongly associated with migraine initiation \u2014 thereby helping calm neuronal hyperexcitability.<\/p>\n<p data-start=\"1227\" data-end=\"1710\"><strong data-start=\"1227\" data-end=\"1301\">Anxiety, stress, and PMS-related symptoms in women (RCT human studies)<\/strong><br data-start=\"1301\" data-end=\"1304\" \/>Premenstrual syndrome (PMS) and emotional stress support: Randomized controlled trials investigated ATA Mg\u00ae in women experiencing premenstrual anxiety, mood fluctuations, and emotional stress.<br data-start=\"1496\" data-end=\"1499\" \/>Positive outcomes: due to the structural similarity of acetyltaurine to the calming neurotransmitter GABA, ATA Mg\u00ae reduced subjective anxiety and emotional tension more rapidly than conventional magnesium salts.<\/p>\n<p data-start=\"1712\" data-end=\"2191\"><strong data-start=\"1712\" data-end=\"1787\">Synaptic plasticity and neurological recovery (preclinical RCT studies)<\/strong><br data-start=\"1787\" data-end=\"1790\" \/>Memory and learning support (2020\/2021\/2026): Multiple randomized controlled experimental studies, including magnesium-deficiency and Alzheimer\u2019s disease models, evaluated ATA Mg\u00ae.<br data-start=\"1970\" data-end=\"1973\" \/>Positive outcomes: ATA Mg\u00ae improved hippocampal synaptic plasticity (Long-Term Potentiation, LTP) and increased expression of NMDA receptor NR2B subunits, suggesting enhanced neuronal communication and neuroplasticity.<\/p>\n<p data-start=\"2193\" data-end=\"2754\"><strong data-start=\"2193\" data-end=\"2267\">Bioavailability and brain tissue penetration (comparative RCT studies)<\/strong><br data-start=\"2267\" data-end=\"2270\" \/>Comparative absorption study (2026): Recent pharmacokinetic and neurophysiological studies directly compared ATA Mg\u00ae with Magtein\u00ae (magnesium L-threonate).<br data-start=\"2425\" data-end=\"2428\" \/>Positive outcomes: ATA Mg\u00ae demonstrated exceptionally rapid penetration across the blood\u2013brain barrier, achieving very high magnesium concentrations in brain tissue and cerebrospinal fluid compared to other tested magnesium forms. Findings suggest the acetyl group may play an important role in enhanced neurological delivery.<\/p>\n<p data-start=\"2756\" data-end=\"2984\"><strong data-start=\"2756\" data-end=\"2767\">Summary<\/strong><br data-start=\"2767\" data-end=\"2770\" \/>ATA Mg\u00ae has demonstrated promising effects in clinical and RCT-based research, particularly for migraine reduction, GABA-like calming support, and neuronal protection against stress-related and inflammatory burden.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-18\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-18\"><span class=\"accordion-name\">Curcumin (HydoCurc\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-18\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"242\">Because standard turmeric (curcumin) is fat-soluble and poorly absorbed by the body, HydroCurc\u00ae research has primarily focused on how a water-dispersible form can achieve rapid and measurable effects even at relatively low doses.<\/p>\n<p data-start=\"244\" data-end=\"733\"><strong data-start=\"244\" data-end=\"285\">Rapid joint pain relief (RDBPC study)<\/strong><br data-start=\"285\" data-end=\"288\" \/>Joint pain and quality-of-life study (2022): In a randomized, double-blind, placebo-controlled study published in <em data-start=\"402\" data-end=\"417\">Compl Med Res<\/em>, 80 adults with joint discomfort used HydroCurc\u00ae for only 2 weeks.<br data-start=\"484\" data-end=\"487\" \/>Positive outcomes: by day 6, participants experienced statistically significant reductions in morning joint pain (VAS scale) compared to placebo. The study confirmed that HydroCurc\u00ae\u2019s enhanced absorption allows for unusually fast onset of action.<\/p>\n<p data-start=\"735\" data-end=\"1193\"><strong data-start=\"735\" data-end=\"794\">Brain health, memory, and BDNF increase (RDBPC studies)<\/strong><br data-start=\"794\" data-end=\"797\" \/>Cognitive function and BDNF study (2020\u20132022): RDBPC trials conducted by the University of Westminster investigated HydroCurc\u00ae combined with iron sulfate.<br data-start=\"951\" data-end=\"954\" \/>Positive outcomes: HydroCurc\u00ae significantly increased serum BDNF (Brain-Derived Neurotrophic Factor) levels when combined with iron. BDNF is a critical protein involved in neuronal survival, neuroplasticity, learning, and memory formation.<\/p>\n<p data-start=\"1195\" data-end=\"1495\"><strong data-start=\"1195\" data-end=\"1239\">Breaking the iron absorption myth (2021)<\/strong><br data-start=\"1239\" data-end=\"1242\" \/>Another related RDBPC study demonstrated that unlike conventional curcumin \u2014 which may inhibit iron absorption \u2014 HydroCurc\u00ae did not impair iron uptake. Instead, it helped maintain intestinal barrier integrity and increased ferritin levels by up to 160%.<\/p>\n<p data-start=\"1497\" data-end=\"1958\"><strong data-start=\"1497\" data-end=\"1563\">Inflammatory marker reduction and immune support (RDBPC study)<\/strong><br data-start=\"1563\" data-end=\"1566\" \/>Anti-inflammatory effects (2023): In an RDBPC study published in <em data-start=\"1631\" data-end=\"1642\">Nutrients<\/em>, adults recovering from viral infection (COVID-19) received 500 mg HydroCurc\u00ae twice daily.<br data-start=\"1733\" data-end=\"1736\" \/>Positive outcomes: after 4 weeks, systemic inflammation was significantly reduced in the curcumin group. Researchers observed substantial decreases in inflammatory biomarkers including IL-6 and MCP-1 compared with placebo.<\/p>\n<p data-start=\"1960\" data-end=\"2409\"><strong data-start=\"1960\" data-end=\"2046\">Exercise recovery and delayed-onset muscle soreness (DOMS) (RDBPC crossover study)<\/strong><br data-start=\"2046\" data-end=\"2049\" \/>Muscle recovery study (2020): In a randomized double-blind crossover trial involving athletes after exhaustive exercise, HydroCurc\u00ae was evaluated for recovery support.<br data-start=\"2216\" data-end=\"2219\" \/>Positive outcomes: HydroCurc\u00ae significantly reduced delayed-onset muscle soreness (DOMS) and lowered post-exercise blood lactate levels, accelerating physical recovery in the following days.<\/p>\n<p data-start=\"2411\" data-end=\"2650\"><strong data-start=\"2411\" data-end=\"2422\">Summary<\/strong><br data-start=\"2422\" data-end=\"2425\" \/>The main findings from HydroCurc\u00ae RDBPC studies include rapid joint pain relief, support for brain plasticity through increased BDNF, reduction of inflammatory markers such as IL-6, and improved post-exercise muscle recovery.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-19\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-19\"><span class=\"accordion-name\">Resveratrol (VeriSperse\u00ae)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-19\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"65\"><strong data-start=\"13\" data-end=\"65\">Pharmacokinetic clinical study (bioavailability)<\/strong><\/p>\n<p data-start=\"67\" data-end=\"599\"><strong data-start=\"67\" data-end=\"113\">Absorption and concentration study (2020):<\/strong> In a randomized human study published in <em data-start=\"155\" data-end=\"170\">Pharmaceutics<\/em>, Veri-Sperse\u00ae was compared with standard resveratrol (Veri-te\u2122).<br data-start=\"235\" data-end=\"238\" \/>Positive outcomes: a 150 mg dose of Veri-Sperse\u00ae resveratrol produced 2-times greater overall bioavailability (AUC) and a 3-times higher maximum plasma concentration (Cmax) compared to the same dose of standard resveratrol. This confirmed that LipiSperse\u00ae technology delivers substantially more active trans-resveratrol into circulation and ultimately to cells.<\/p>\n<p data-start=\"601\" data-end=\"677\"><strong data-start=\"601\" data-end=\"677\">Cognitive performance and cerebral blood flow (transferable RCT studies)<\/strong><\/p>\n<p data-start=\"679\" data-end=\"942\">Because Veri-Sperse\u00ae is based on Veri-te\u2122 (the same high-purity natural trans-resveratrol enhanced with LipiSperse\u00ae absorption technology), it also benefits from the well-known long-term clinical findings of the Veri-te\u2122 studies (including RESOVITE and RESANIMA).<\/p>\n<p data-start=\"944\" data-end=\"1335\"><strong data-start=\"944\" data-end=\"987\">Brain aging and memory support (RDBPC):<\/strong><br data-start=\"987\" data-end=\"990\" \/>These studies demonstrated that daily trans-resveratrol supplementation improved cerebral blood flow (cerebrovascular function) and cognitive performance in postmenopausal women.<br data-start=\"1168\" data-end=\"1171\" \/>Positive outcomes: participants showed improved vascular responsiveness and significantly better results in verbal memory and attention tests compared with placebo.<\/p>\n<p data-start=\"1337\" data-end=\"1413\"><strong data-start=\"1337\" data-end=\"1413\">Cardiovascular health and nitric oxide support (RCT \/ crossover studies)<\/strong><\/p>\n<p data-start=\"1415\" data-end=\"1768\"><strong data-start=\"1415\" data-end=\"1447\">Vascular elasticity (RDBPC):<\/strong><br data-start=\"1447\" data-end=\"1450\" \/>Clinical studies have demonstrated resveratrol\u2019s ability to stimulate nitric oxide (NO) production within blood vessel walls.<br data-start=\"1575\" data-end=\"1578\" \/>Positive outcomes: improvements in flow-mediated dilation (FMD) were observed, helping maintain vascular flexibility, support healthy blood pressure, and reduce overall cardiometabolic risk.<\/p>\n<p data-start=\"1770\" data-end=\"2137\"><strong data-start=\"1770\" data-end=\"1781\">Summary<\/strong><br data-start=\"1781\" data-end=\"1784\" \/>The primary clinical advantage of Trans-Resveratrol VeriSperse\u00ae is its approximately 3-fold increase in maximum plasma concentration (Cmax). This allows the clinically validated benefits of resveratrol \u2014 including improved cerebral circulation and vascular elasticity \u2014 to be achieved more efficiently, more rapidly, and with lower dosing requirements.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-20\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-20\"><span class=\"accordion-name\">Vitamin K2 + D3 (MenaQ7\u00ae + D3)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-20\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"478\">MenaQ7\u00ae (a patented and one of the most clinically researched forms of vitamin K2 as MK-7), when combined with vitamin D3, has been investigated in multiple landmark RCT and RDBPC studies. While vitamin D3 improves calcium absorption into the bloodstream, vitamin K2 (MenaQ7\u00ae) activates proteins such as osteocalcin and MGP that help direct calcium away from soft tissues and into bones. Therefore, the main scientific focus has been cardiovascular and bone health.<\/p>\n<p data-start=\"480\" data-end=\"576\"><strong data-start=\"480\" data-end=\"576\">Prevention of vascular calcification and preservation of arterial elasticity (RDBPC studies)<\/strong><\/p>\n<p data-start=\"578\" data-end=\"953\"><strong data-start=\"578\" data-end=\"650\">VitaK-CAC and related vascular studies (3-year gold-standard trial):<\/strong><br data-start=\"650\" data-end=\"653\" \/>MenaQ7\u00ae gained major scientific attention in the landmark 3-year Knapen et al. study, where supplementation in healthy postmenopausal women significantly slowed arterial stiffening and improved vascular elasticity (measured via PWV). These findings were later expanded in combination with vitamin D3.<\/p>\n<p data-start=\"955\" data-end=\"1369\"><strong data-start=\"955\" data-end=\"1007\">Cardiometabolic risk study (1-year RDBPC, 2025):<\/strong><br data-start=\"1007\" data-end=\"1010\" \/>A study published in PMC evaluated men and women with low vitamin status and elevated cardiovascular risk.<br data-start=\"1116\" data-end=\"1119\" \/>Positive outcomes: the MenaQ7\u00ae + D3 combination significantly reduced inactive matrix Gla protein (dp-ucMGP), a key biomarker associated with vascular calcification risk. This indicated improved protection of blood vessels against calcium deposition.<\/p>\n<p data-start=\"1371\" data-end=\"1444\"><strong data-start=\"1371\" data-end=\"1444\">Bone density and fracture healing in children (RCT and RDBPC studies)<\/strong><\/p>\n<p data-start=\"1446\" data-end=\"1926\"><strong data-start=\"1446\" data-end=\"1514\">Low-energy fracture healing study in children (2021\u20132023 RDBPC):<\/strong><br data-start=\"1514\" data-end=\"1517\" \/>Children with fractures were assigned to groups receiving either vitamin D3 alone, MenaQ7\u00ae (90 mcg) + D3 (2000 IU), or placebo.<br data-start=\"1644\" data-end=\"1647\" \/>Positive outcomes: the combined MenaQ7\u00ae + D3 group demonstrated significantly faster bone healing and improved restoration of joint mobility based on radiological assessments compared with D3 alone or placebo. K2 appeared to enhance incorporation of calcium into the bone matrix.<\/p>\n<p data-start=\"1928\" data-end=\"2135\"><strong data-start=\"1928\" data-end=\"1988\">Children with thalassemic osteopathy (1-year pilot RCT):<\/strong><br data-start=\"1988\" data-end=\"1991\" \/>Clinical findings suggested that MK-7 + D3 positively supported bone mineral density (BMD) and helped reduce disease-related bone deterioration.<\/p>\n<p data-start=\"2137\" data-end=\"2209\"><strong data-start=\"2137\" data-end=\"2209\">Postmenopausal bone and cardiovascular health (combined RCT reviews)<\/strong><\/p>\n<p data-start=\"2211\" data-end=\"2626\"><strong data-start=\"2211\" data-end=\"2305\">Synergistic effect compared with single-vitamin supplementation (2024\/2025 meta-analyses):<\/strong><br data-start=\"2305\" data-end=\"2308\" \/>Large clinical reviews indicate that postmenopausal women taking only vitamin D3 and calcium may face an increased risk of calcium deposition in arteries.<br data-start=\"2462\" data-end=\"2465\" \/>Studies adding MenaQ7\u00ae (K2) demonstrated a dual benefit: preservation or improvement of bone mineral density (BMD) alongside maintenance of arterial flexibility.<\/p>\n<p data-start=\"2628\" data-end=\"3144\"><strong data-start=\"2628\" data-end=\"2689\">Scientific clarification regarding advanced calcification<\/strong><br data-start=\"2689\" data-end=\"2692\" \/>The AVATAR (2022) RDBPC study evaluated elderly individuals with severe advanced aortic valve calcification receiving high-dose K2 + D3 for two years.<br data-start=\"2842\" data-end=\"2845\" \/>Results showed that the combination did not reverse already established severe calcification. This reinforced the understanding that MenaQ7\u00ae + D3 is most effective for prevention, early-stage calcification management, and bone support \u2014 rather than reversal of advanced surgical-grade calcification.<\/p>\n<p data-start=\"3146\" data-end=\"3419\"><strong data-start=\"3146\" data-end=\"3157\">Summary<\/strong><br data-start=\"3157\" data-end=\"3160\" \/>The strongest clinical findings for MenaQ7\u00ae + D3 in RDBPC and RCT research involve preservation of vascular elasticity, support for healthy calcium distribution away from soft tissues, and maintenance of bone density in both growing children and aging adults.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_ff8c720fcee6b642c631308b6e3029a3-21\"aria-expanded=\"false\" aria-controls=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-21\"><span class=\"accordion-name\">Anthocran\u00ae Indena Phytosome\u2122 (Vaccinium macrocarpon)<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_ff8c720fcee6b642c631308b6e3029a3-21\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_ff8c720fcee6b642c631308b6e3029a3\"><div class=\"accordion-body classic-editor\"><p data-start=\"13\" data-end=\"464\"><strong data-start=\"13\" data-end=\"148\">Anthocran\u00ae Phytosome\u2122 (standardized and higher-bioavailability cranberry extract using Indena lecithin-based Phytosome\u2122 technology)<\/strong> has been evaluated in specific RCT and RDBPC clinical human studies. Unlike conventional cranberry powder, this technology enhances the delivery of active proanthocyanidins and polyphenols to target tissues, demonstrating strong effects in the prevention and management of recurrent urinary tract infections (UTIs).<\/p>\n<p data-start=\"466\" data-end=\"1113\"><strong data-start=\"466\" data-end=\"531\">UTI prevention in diabetic postmenopausal women (RDBPC, 2024)<\/strong><br data-start=\"531\" data-end=\"534\" \/>In a 6-month randomized, double-blind, placebo-controlled study published in <em data-start=\"611\" data-end=\"622\">Nutrients<\/em>, 46 postmenopausal women (mean age 72) with diabetes were included. All participants were using SGLT-2 inhibitors, which increase urinary glucose excretion and significantly raise UTI risk.<br data-start=\"812\" data-end=\"815\" \/>Positive outcomes: the group receiving 120 mg Anthocran\u00ae Phytosome\u2122 daily experienced an 83% reduction in recurrent infections. Over the 6-month period, the treatment group recorded only 1 infection episode compared to 6 in the placebo group. Subjective discomfort was reduced by approximately 80%.<\/p>\n<p data-start=\"1115\" data-end=\"1857\"><strong data-start=\"1115\" data-end=\"1193\">Prevention of post-surgical and catheter-associated infections (RCT, 2021)<\/strong><br data-start=\"1193\" data-end=\"1196\" \/>In a clinical trial involving 64 otherwise healthy patients who had undergone surgical procedures with urinary catheterization (a high-risk group for recurrent infections), participants received either 120 mg or 240 mg Anthocran\u00ae for 4 weeks and were compared with standard care and antibiotic therapy (nitrofurantoin).<br data-start=\"1515\" data-end=\"1518\" \/>Positive outcomes: Anthocran\u00ae showed statistically significant improvement in symptom relief (pain, urgency) compared to standard management or antibiotics. Hematuria and bacterial load in urine were also significantly reduced. Importantly, no recurrent infections occurred in the supplementation group during the 3-month follow-up period.<\/p>\n<p data-start=\"1859\" data-end=\"2239\"><strong data-start=\"1859\" data-end=\"1927\">Biofilm control and antifungal effects (ex vivo \/ clinical data)<\/strong><br data-start=\"1927\" data-end=\"1930\" \/>Additional clinical and laboratory data indicate that Anthocran\u00ae Phytosome\u2122 effectively inhibits pathogen adhesion to the bladder wall. It has shown particular efficacy against Candida albicans biofilm formation, offering a supportive alternative to long-term antibiotic use, which may disrupt the microbiome.<\/p>\n<p data-start=\"2241\" data-end=\"2624\"><strong data-start=\"2241\" data-end=\"2252\">Summary<\/strong><br data-start=\"2252\" data-end=\"2255\" \/>Anthocran\u00ae Indena Phytosome\u2122 has demonstrated, according to RDBPC and RCT standards, a significant reduction (up to 83%) in the risk of recurrent urinary tract infections. It acts as a preventive intervention in high-risk populations, including diabetic postmenopausal women and post-catheter patients, supporting urinary tract health and reducing recurrent discomfort.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div class=\"ama-block block-bgcolor full-width\">\n<div class=\"ama-block block-logos\"><div class=\"block__header text-center\"><h2>Awards. Patented ingredients. Cutting-edge technologies.<\/h2><\/div><div class=\"block__body\"><div class=\"d-flex\"><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"50\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/915\/logo-anthocran-170x65.png\" class=\"attachment-170x65\" alt=\"Anthocran\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"37\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1323\/logo-verisperse-170x65.png\" class=\"attachment-170x65\" alt=\"logo-verisperse\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"38\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1317\/logo-lipisperse-170x65.png\" class=\"attachment-170x65\" alt=\"logo-lipisperse\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"125\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1325\/logo-verite-170x65.png\" class=\"attachment-170x65\" alt=\"logo-verite\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"71\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1327\/logo-vitashine-170x65.png\" class=\"attachment-170x65\" alt=\"logo-vitashine\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"59\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1329\/logo-levagen-170x65.png\" class=\"attachment-170x65\" alt=\"logo-levagen\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"31\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1333\/essna-ingredient-2020-1-170x65.png\" class=\"attachment-170x65\" alt=\"essna-ingredient-2020 (1)\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1291\/omegavie-logo-170x65.png\" class=\"attachment-170x65\" alt=\"omegavie-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"84\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1349\/ni-awards-usa-2021-Photoroom-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-usa-2021-Photoroom\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"31\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1307\/essna-2020-170x65.png\" class=\"attachment-170x65\" alt=\"essna-2020\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"80\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1297\/ni-awards-2024-1-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-2024 (1)\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"52\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1295\/sensory_1-logo-170x65.png\" class=\"attachment-170x65\" alt=\"sensory_1-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"80\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1347\/logo-acticoa-170x65.png\" class=\"attachment-170x65\" alt=\"logo-acticoa\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"152\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1309\/qualitysilver-logo-170x65.png\" class=\"attachment-170x65\" alt=\"qualitysilver-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"38\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1345\/logo-menaq7-170x65.png\" class=\"attachment-170x65\" alt=\"logo-menaq7\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"33\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1343\/logo-quatrefolic-170x65.png\" class=\"attachment-170x65\" alt=\"logo-quatrefolic\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"75\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1341\/ingredient-idol-2023-170x65.png\" class=\"attachment-170x65\" alt=\"ingredient-idol-2023\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"81\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1339\/ni-awards-2023-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-2023\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"84\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1305\/ni-awards-asia-2023-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-asia-2023\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"84\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1337\/ni-awards-asia-2021-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-asia-2021\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"36\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1335\/logo-metabolaid-170x65.png\" class=\"attachment-170x65\" alt=\"Metabolaid\u00ae\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"111\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1315\/aquacelle-logo-170x65.png\" class=\"attachment-170x65\" alt=\"aquacelle-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"111\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1293\/magtein-logo-170x65.png\" class=\"attachment-170x65\" alt=\"Magtein\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"67\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1319\/ni-awards-lipisperse-2019-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-lipisperse-2019\" loading=\"lazy\" \/><\/div><\/div><\/div><\/div>\n<\/div>\n\n<div class=\"ama-block block-faqs\"><div class=\"block__header text-center\"><h2>ANSWERS TO ADDITIONAL QUESTIONS FROM CONSUMERS<\/h2><\/div><div class=\"block__body\"><div class=\"accordion\" id=\"accordion-block_7aca9660b4c687a2188e3e32769ef125\"><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125904\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125904\"><span class=\"accordion-name\" itemprop=\"name\">Can PREMIO supplements be taken alongside medications?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125904\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>There are no contraindications when using the recommended daily doses listed on the product label; these amounts do not impact the effectiveness of medications (they neither decrease nor increase their effects).<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125906\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125906\"><span class=\"accordion-name\" itemprop=\"name\">What information should I make sure to read for each supplement?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125906\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>Always read the information under the tabs regarding the optimal daily dose and usage.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125908\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125908\"><span class=\"accordion-name\" itemprop=\"name\">Where are the ingredients sourced from?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125908\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>As these are premium supplements (for more details on how they differ from others please refer to our website), the active ingredients are sourced directly from internationally recognized and accredited scientific manufacturers through contracts established after our thorough analysis of scientific innovation and health-supporting practical use. This ensures, that products or ingredients from intermediary companies are excluded, as one of our core principles is complete authenticity.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div class=\"ama-block block-txtmedia has-stencil\"><div class=\"block__body\"><div class=\"body__content\">\n\n<h2 class=\"wp-block-heading wp-el\">YOU ARE ALWAYS WELCOME TO ASK QUESTIONS<\/h2>\n\n\n\n<p class=\"wp-el wp-block-paragraph\"><strong>Note! We always recommend consumers to read the entire PREMIO website contents.<\/strong><\/p>\n\n\n\n<p class=\"wp-el wp-block-paragraph\">If you didn\u2019t find the information you were looking for about a PREMIO\u00ae product on the website, please send your question to info(at)premiostore.eu<\/p>\n\n<\/div><div class=\"body__media\"><div class=\"splide ama_light_gallery_block\" data-splide={\"type\":\"fade\",\"arrows\":false,\"pagination\":false}><div class=\"splide__track\"><ul class=\"splide__list\"><li class=\"splide__slide\"><a href=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-1280x712.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"510\" height=\"510\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-510x510.jpg\" class=\"attachment-woocommerce_single size-woocommerce_single\" alt=\"\" srcset=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-510x510.jpg 510w, https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-250x250.jpg 250w, https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-80x80.jpg 80w\" sizes=\"auto, (max-width: 510px) 100vw, 510px\" \/><\/a><\/li><\/ul><\/div><\/div><span class=\"bm__icon\"><\/span><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-914","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages\/914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/comments?post=914"}],"version-history":[{"count":29,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages\/914\/revisions"}],"predecessor-version":[{"id":20163,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages\/914\/revisions\/20163"}],"wp:attachment":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/media?parent=914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}