{"id":914,"date":"2026-02-04T09:49:19","date_gmt":"2026-02-04T07:49:19","guid":{"rendered":"https:\/\/premiostore.eu\/tippteadus\/"},"modified":"2026-04-05T13:46:43","modified_gmt":"2026-04-05T10:46:43","slug":"tippteadus","status":"publish","type":"page","link":"https:\/\/premiostore.eu\/en\/tippteadus\/","title":{"rendered":"TOP-SCIENCE"},"content":{"rendered":"<div class=\"ama-block block-accordion\"><div class=\"block__header text-center\"><h2>Selection of scientific and clinical studies conducted with the world\u2019s top preparations<\/h2><\/div><div class=\"block__body\"><div class=\"accordion\" id=\"accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-1\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-1\"><span class=\"accordion-name\">Astaxanthin<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-1\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>A Randomized Double-Blind Placebo-Controlled Trial:\u00a0<\/strong>Astaxanthin (AstaReal\u00ae) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial. Advances in Therapy, Hecht et al., 2025.<\/p>\n<p><strong>A comprehensive review:\u00a0<\/strong>Health benefits of astaxanthin against age-related diseases of multiple organs. Critical reviews in Food science and Nutrition. Alugoju et al., 2022.<\/p>\n<p><strong>A critical review:\u00a0<\/strong>The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans. Nutrients, Queen et al., 2024.<\/p>\n<p><strong>A randomized control trial<\/strong>: Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males: Nutrients, Moqaddam et al., 2024<\/p>\n<p><strong>A systematic review and meta-analysis<\/strong>: Antioxidant Lipid Supplement on Cardiovascular Risk Factors: Nutrients, Wan et al., 2024.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-2\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-2\"><span class=\"accordion-name\">Berberine aristata<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-2\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>Berbevis and Metabolic Health &amp; Weight Management:\u00a0<\/strong>Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials. Frontiers in Pharmacology. Liu et al., 2025.<\/p>\n<p><strong>Berbevis and Polycystic Ovary Syndrome (PCOS):\u00a0<\/strong>Effect of Berberine Phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial. Front. Pharmacol., Di Pierro et al., 2023.<\/p>\n<p><strong>A clinical trial:\u00a0<\/strong>Borderline hyperlipidemia preventive management with Berberine PL in asymptomatic prevention of early atherosclerosis. Minerva Gastroenterol, Cesarone et al., 2024.<\/p>\n<p><strong>A Meta-analysis and Systematic review.<\/strong>The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. J Transl. Med. Nie et al, 2024<\/p>\n<p><strong>A Systematic Review and Meta-Analysis of Randomized Clinical Trials:<\/strong>\u00a0Efficacy and Safety of Berberine Alone for Several Metabolic Disorders. Front. Pharmacol. Ye et al, 2021.<\/p>\n<p><strong>A randomized double-blind placebo-controlled clinical trial:<\/strong>\u00a0Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. European Review Medical and Pharmacological Sciences, Rondanelli et al., 2023.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-3\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-3\"><span class=\"accordion-name\">Melissa officinalis<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-3\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>PREMIO re-laxation and sleep quality<\/strong>.\u00a0 Effects of\u00a0<em>Melissa officinalis<\/em>\u00a0Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study. Nutrients, Di Pierro et al., 2024\/2025<\/p>\n<p><strong>PREMIO re-laxation and mental well-being:\u00a0<\/strong>\u00a0Three-week daily supplementation of a 200 or 400 mg lecithin-based delivery form of Melissa counterbalances emotional distress symptoms. J Food Science and Nutrition Research. Rondanelli et al., 2024.<\/p>\n<p><b>Randomized, double-blinded, placebo-controlled clinical trial \u2013 emotional distress and poor sleep conditions:<\/b>\u00a0The possible \u201ccalming effect\u201d of subchronic supplementation of a standardized phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomized, double-blinded, placebo-controlled clinical trial. Front Pharmacol, Bano et al., 2023.<\/p>\n<p><b>Potential neuromodulator for emotional distress and related conditions:\u00a0<\/b>An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions. Front Mol Biosci, Kara et al., 2024.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-4\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-4\"><span class=\"accordion-name\">Hibiscus sabdariffa and Lippia citriodora<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-4\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>A double-blind, placebo-controlled, randomized clinical study:<\/b>\u00a0Effectiveness of a Polyphenol-Enriched Blend on Weight Management and Metabolic Syndrome-Related Parameters in Healthy Overweight Adults, Appl. Sci. Mart\u00ednez-Rodr\u00edguez et al., 2024<\/p>\n<p><b>Randomized, placebo-controlled, double-blind clinical study about MetabolAid\u00ae:\u00a0<\/b>Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food &amp; Function, Boix-Castejon et al., 2018.<\/p>\n<p><b>Randomized controlled clinical study:\u00a0<\/b>Diferential efects of a combination of Hibiscus sabdarifa and Lippia citriodora polyphenols in overweight\/obese subjects: A randomized controlled trial. Scientific Reports, Herranz-Lopes et al., 2019.<\/p>\n<p><b>Randomized, placebo-controlled, double-blind clinical study:<\/b>A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects. Foods, Marhuenda et al., 2020.<\/p>\n<p><b>Randomized, placebo-controlled, double-blind clinical trial:\u00a0<\/b>A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of a Polyphenolic Extract ( Hibiscus sabdariffa and Lippia citriodora) for Reducing Blood Pressure in Prehypertensive and Type 1 Hypertensive Subjects. Molecules, Marhuenda et al., 2021.<\/p>\n<p><b>Randomized controlled clinical study:<\/b>Effect of metabolaid\u00ae on pre- and stage 1 hyperten-sive patients: A randomized controlled trial. J Functional Foods, Boix-Castejon et al., 2021.<\/p>\n<p><b>Randomized, placebo-controlled, double-blind, cross-over clinical study:<\/b>Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial. European J Nutrition, Serna et al, 2022.<\/p>\n<p><b>Obesity and its complications:\u00a0<\/b>Metabolaid\u00ae Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation (animal study), Nutrients, Lee et al., 2018.<\/p>\n<p><b>Gut microbiota-modulating properties of Metabolaid\u00ae:\u00a0<\/b>Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites. J. Functional Foods, Silva et al., 2022.<\/p>\n<p><b>New Mobile App and using Metabolaid\u00ae:\u00a0<\/b>New App-Based Dietary and Lifestyle Intervention on Weight Loss and Cardiovascular Health, Sensors (Basel) Mart\u00ednez-Rodr\u00edguez et al. 2022. Metabolaid + mobile app (with daily reminders to follow healthy lifestyle recommendations) increased physical activity and overall improved blood pressure and fat mass levels when compared with a group performing the same intervention without mobile application.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-5\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-5\"><span class=\"accordion-name\">Palmitoylethanolamide<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-5\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>PREMIO\u00ae endokannabinoid (Levagen\u00ae+)<\/strong><\/p>\n<p>Allj\u00e4rgnevad teadust\u00f6\u00f6d t\u00f5endavad antud preparaadi teadus-kliinilist toimet:<\/p>\n<p><strong>Palmityolethanolamide (Levagen\u00ae+) for acute menstrual pain:<\/strong>\u00a0 a randomized, crossover, double-blind, placebo-controlled trial. Women &amp; Health, Rao et al., 2025<\/p>\n<p><strong>The Effect of Topical Palmitoylethanolamide (PlexoZome\u00ae Levagen\u00ae) on Relief of Post Exercise Knee Joint Pain<\/strong>\u00a0\u2013 A Randomised Double-Blind Controlled Study, J Altern Complementary\u00a0 &amp; Integrative Medicine,<em>\u00a0\u00a0<\/em>Pellow et al., 2025<\/p>\n<p><strong>Levagen+ and physiological resilience to stress.\u00a0<\/strong>The effects of formulated palmitoyl\u00adethanolamide supplementation on indicators of stress and heart rate variability in female university students: a double blind placebo-controlled cross-over trial. Nutr. Deb et al., 2025.<\/p>\n<p><b>Levagen\u00ae+ and acute menstrual pain:<\/b>\u00a0Effect of Levagen\u00ae+ (PEA) compared to a placebo on acute menstrual pain in an adult population \u2013 a double-blind, randomised, placebo controlled, cross-over clinical trial (manuscript in preparation, Amanda Rao et al., 2024)<\/p>\n<p><b>Levagen+ and Cognitive Function and BDNF:<\/b>\u00a0Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults (RDBPC trial), Nutrients, Kim et al., 2024.<\/p>\n<p><b>Levagen\u00ae+ and Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training:<\/b>\u00a0The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial, Sport medicine, Huschtscha et al., 2024<\/p>\n<p><b>Levagen\u00ae+ and Allergic Rhinitis:<\/b>\u00a0The Effect of Levagen\u00ae+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis- A Double-Blind Placebo-Controlled Trial, Nutrients, Briskey et al., 2023.<\/p>\n<p><b>Levagen\u00ae+ and diabetic-related peripheral neuropathic pain:<\/b>\u00a0A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology, Pickering et al., 2022.<\/p>\n<p><b>Levagen+ and Headache Pain:<\/b>\u00a0Efficacy of Palmitoylethanolamide (Levagen\u00ae+) Compared to Ibuprofen for Reducing Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial. Food and Nutrition Sciences, Briskey et al., 2022.<\/p>\n<p><b>Levagen\u00ae+ and incidence and symptoms of Upper Respiratory Tract Infection (DBRPC Trial):\u00a0<\/b>The Efficacy of Palmitoyl-ethanolamide (Levagen\u00ae+) on the Incidence and Symptoms of Upper Respiratory Tract Infection\u2014A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients, Rao, et al., 2023.<\/p>\n<p><b>Levagen\u00ae+ and migraine pain:<\/b>\u00a0Effectiveness of Palmitoylethanolamide (Levagen\u00ae+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants\u2014A Double-Blind Randomised Controlled Study. Pharmaceuticals, 17, 145, Briskey et al., 2024.<\/p>\n<p><b>PK study \u2013 Levagen\u00ae+:<\/b>\u00a0Increased absorption of Palmitoylethanolamide using a novel dispersion technology system (LipiSperse\u00ae). Nutriceuticals Food Sci, Briskey et al., 2020.<\/p>\n<p><b>Clinical Trial \u2013 Exercise study Levagen\u00ae+:<\/b>\u00a0The effect of orally dosed Levagen\u00ae+ (palmitoylethanolamide) on exercise recovery in healthy males. Nutrients, Mallard et al., 2020.<\/p>\n<p><b>Clinical Trial \u2013 Join pain Levagen\u00ae+:<\/b>\u00a0The effect of a dispersible palmitoylethanolamide Levagen\u00ae+ compared to a placebo for reducing joint pain in an adult population. Inflammopharmacology, Steels et al., 2019.<\/p>\n<p><b>Sleep study \u2013 Levagen\u00ae+:<\/b>\u00a0Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study, Sleep Sci Pract, Rao et al, 2021.<\/p>\n<p><b>Joint\/Knee Pain Study \u2013 Levagen\u00ae+:<\/b>\u00a0A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Steels et al., 2019.<\/p>\n<p><b>Lifetime Management \u2013 Levagen\u00ae+ :<\/b>\u00a0Palmitoylethanolamide: A natural compound for health management. Int J Mol Sci, Clayton et al., 2021.<\/p>\n<p><b>Covid Study \u2013 Levagen\u00ae+ :<\/b>\u00a0Effects of palmitoylethanolamide on proinflammatory markers in adults recently diagnosed with COVID-19. Current Developments in Nutrition, Fessler et al., 2022.<\/p>\n<p><b>Treatment of Chronic Pain and PEA:<\/b>\u00a0A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients, Lang-Illievich et al., 2023.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-6\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-6\"><span class=\"accordion-name\">Magnesium L-threonate<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-6\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Randomized Controlled Trial- Cognition, memory, Magtein\u00ae:<\/b>Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems Sleep medicine, X8, Hausenblas et al, 2024.<\/p>\n<p><b>A Randomized, Double-Blind, Placebo-Controlled Trial \u2013 cognitive impairment, magnesium-L-threonate:<\/b>Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial, J Alzheimers Dis, Guosong et al, 2016.<\/p>\n<p><b>Randomized Controlled Trial- Cognition, memory, magtein:<\/b>\u00a0A Magtein\u00ae, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, Zhang et al., 2022.<\/p>\n<p><b>Randomized Controlled Trial \u2013 Cancer pain, constipation:<\/b>\u00a0Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients- A randomized, double-blind, placebo-controlled trial, Cancer Med, Wu et al., 2023.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-7\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-7\"><span class=\"accordion-name\">Quercetin<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-7\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>RDBCT:<\/strong>\u00a0Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial, Eur J Nutr, \u00a0Mar 10;64(3):117, Nishikawa et al., 2025.<\/p>\n<p><strong>RDBPC Trial:<\/strong>\u00a0\u00a0Quer\u00ad\u00adcetin intervention reduced hepatic fat deposition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled crossover clinical trial<strong>.<\/strong>\u00a0 Am J Clin Nutr, Sep;120(3):507-517, Li et al., 2024<strong>.<\/strong><\/p>\n<p><strong>DBPC clinical trial:\u00a0<\/strong>Two-month period of 500 mg lecithin-based delivery form of quercetin (Quercetin Phytosome\u2122) daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial. Biomed Pharmacother, Nov:167:115453, Rondanelli et al., 2023.<\/p>\n<p><b>Advantages of the LipiSperse\u00ae technology platform:<\/b>\u00a0patented, supported by human pharmacokinetic studies, award winning (direct communication from company).<\/p>\n<p><b>Randomized, placebo-controlled, double-blind parallel-group study:\u00a0<\/b>Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci, Yamada et al., 2022.<\/p>\n<p><b>Quercetin and different cancers:<\/b>\u00a0The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update. Front. Immunol. Lofti et al., 2023.<\/p>\n<p><b>Quercetin -inflammation, diabetes and diabetic complications:<\/b>\u00a0Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications. Review. Crit. Rev in Food Sci and Nutrition, Yan et, 2022.<\/p>\n<p><b>Quercetin and cardiac arrhythmia:<\/b>\u00a0Roles and mechanisms of quercetin on cardiac arrhythmia: A review. Biomedicine &amp; Pharmacotherapy, Zou et al., 2022.<\/p>\n<p><b>Quercetin \u2013 dyslipidemia, hypertension, metabolic syndrome, obesity:<\/b>\u00a0Quercetin and metabolic syndrome: A review, Phytother Res, Hosseini et al., 2021.<\/p>\n<p><b>Quercetin \u2013 diabetes and cancer:<\/b>\u00a0Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer. Diseases, Michala, Pritsa, 2022.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-8\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-8\"><span class=\"accordion-name\">Ubiquinone<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-8\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>PK Study \u2013 AquaCelle\u00ae CoQ10:\u00a0<\/b>The impact of micelle size and increased absorption of ubiquinone using a novel delivery system (AquaCelle\u00ae). David Briskey, Andrew T Sax, Alistair R Mallard, Charlie Ng and Amanda Rao. International Journal of Pharmacokinetics vol.4, no.2. doi.org\/10.4155\/ipk-2019-0004<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-9\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-9\"><span class=\"accordion-name\">OMEGA-3<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-9\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Chronic kidney disease and large metaanalysis:\u00a0<\/b>Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ, Ong et al., 2023<\/p>\n<p>(Conclusion: higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. The results support a favourable role for seafood derived n-3 PUFAs in preventing CKD)<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-10\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-10\"><span class=\"accordion-name\">Nicotinamide riboside<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-10\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Randomized clinical trials: Nicotinamide riboside and PAD:<\/b>\u00a0Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial, Nature Communications, McDermott et al., 2024.<\/p>\n<p><b>Nicotinamide riboside \u2013 safety, bioavailability, metabolic disorders, age-associated diseases, COVID-19:\u00a0<\/b>Nicotinamide Riboside \u2013 The Current State of Research and Therapeutic Uses, Nutrients, Mehmel et al., 2020.<\/p>\n<p><b>Muscle mitochondrial biogenesis, gut microbiota:\u00a0<\/b>Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv . 2023, Lapatto et al., 2023.<\/p>\n<p><b>Clinical trials, Nicotinamide riboside, Physiology, Successful aging:\u00a0<\/b>Dietary supplementation with NAD+ -Boosting Compounds in Humans: Current Knowledge and Future Directions, J Gerontology, Freeberg et al., 2023.<\/p>\n<p><b>Rheumatoid Arthritis:\u00a0<\/b>Preclinical characterization of pharmacological NAD+ boosting as a promising therapeutic approach in Rheumatoid Arthritis. Arthritis Rheumatol, Perez-Sanchez et al., 2023.<\/p>\n<p><b>Chronic kidney disease:\u00a0<\/b>Randomized crossover clinical trial of coenzyme Q10 and nicotinamide ribosome in chronic kidney disease. JCI Insight. Ahmadi et al., 2023.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-11\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-11\"><span class=\"accordion-name\">Methylcobalamine<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-11\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Methylcobalamin \u2013 anemia, fatigue, weakness, memory loss, hyperhomocysteinemia:<\/b>\u00a0Ramifications of Vitamin B12 Deficiency and its Beneficial Effects. Int J Innovative Sci Res Technology, Mukherjee et al., 2023.<\/p>\n<p><b>Neuropsychiatric aspects:<\/b>\u00a0Changes of Serum Homocysteine and Vitamin B12, but Not Folate Are Correlated With Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Case-Control Studies. Front. Psychiatry, Yan et al., 2022.<\/p>\n<p><b>Vitamin B12 and Alzheimer\u2019s Disease:<\/b>\u00a0Review. Mechanistic Link between Vitamin B12 and Alzheimer\u2019s Disease. Biomolecules, Lauer et al., 2022.<\/p>\n<p><b>Frailty syndrome:<\/b>\u00a0B12 levels and frailty syndrome. J Frailty, Sarcopenia, Falls. Pyrgioti and Karakousis, 2022.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-12\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-12\"><span class=\"accordion-name\">Melatonin<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-12\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Meta-analysis \u2013 Melatonin and sleep quality:\u00a0<\/b>Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. J Neurol, Fatemeh et al., 2022<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-13\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-13\"><span class=\"accordion-name\">Curcuma longa<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-13\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>HydroCurc\u00ae \u00a0a clinically proven, award-winning, cold-water dispersible curcumin was in 2025 granted USA patent titled \u201cLIQUID DISPERSIBLE CURCUMINOID COMPO-SITIONS AND METHODS OF IMPROVING COGNITIVE FUNCTION\u201d\u00a0<\/strong>this covers the clinical data backing HydoCurc\u00ae\u2019s ability to improve bioavailability and increase the serum levels of brain-derived neurotrophic factor (BDNF) and its effect is further enhanced when the dispersible curcuminoid composition is combined with, or co-administered with, an iron supplement.<\/p>\n<p><strong>HydroCurc\u00ae and improved iron uptake and ferritin level:<\/strong>\u00a0 Co-administration of curcumin forms with supplemental iron: a study of effects on iron absorption and intestinal cellular health. Food Func. G\u00e1mez-Fern\u00e1ndez et al., 2025.<strong>\u00a0<\/strong><\/p>\n<p><strong>HydroCurc\u00ae and recovery.\u00a0<\/strong>The dose\u2013response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise\u2010induced muscle damage in males. Physiological Reports, 2025.<\/p>\n<p><strong>HydroCurc\u00ae and recovery:\u00a0<\/strong>Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation. J Dietary Supplements<em>,\u00a0<\/em>Mallard et al. 2025.<\/p>\n<p><strong>HydroCurc\u00ae and\u00a0 Post-Viral Recovery: IL-6 and MCP-1\u00a0<\/strong>Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial. (updated in 2025)<em>\u00a0Nutrients.<\/em><\/p>\n<p><strong>HydroCurc\u00ae and Joint Pain reduction and Morning Relief.<\/strong>\u00a0The Effect of a Dispersible Curcumin (HydroCurc\u00ae) Compared to a Placebo for Reducing Joint Pain in an Adult Population \u2013 A Randomised Double-Blind Study (republished and featured\u00a0 in 2025). Complementary Medicine Research, 2025.<\/p>\n<p><strong>RDBPC clinical trial:<\/strong>\u00a0Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Pain Res. 18:411\u2013427, Thanawala et el., 2025.<\/p>\n<p><strong>DBPC trial:\u00a0<\/strong>The effectiveness of curcumin as a safe agent on hearing threshold improvement in patients with chronic kidney disease: a double-blind, placebo-controlled trial. Scientific Reports (Nature), Doostkam et al. 2024.<\/p>\n<p><b>PK study \u2013 HydroCurc\u00ae:<\/b>\u00a0Increased absorption curcumin using a novel dipersion technology system (LipiSperce\u00ae). Eur J Nutr, Briskey et al., 2019.<\/p>\n<p><b>Clinical Trial \u2013 DOMS study HydroCurc\u00ae:\u00a0<\/b>Curcumin improves delayed onset muscle soreness and post-exercise lactate accumulation. J Dietary Suppl. Mallard et al., 2020.<\/p>\n<p><b>BDNF Study \u2013 HydroCurc\u00ae:<\/b>\u00a0Co-administration of iron and bioavailable curcumin supplement increases serum BDNF levels in healthy adults. Antioxidants, Lorinzova et al., 2020.<\/p>\n<p><b>Iron Study \u2013 HydroCurc\u00ae + iron:<\/b>\u00a0Acute administration of bioavailable curcumin alongside ferrous sulfate supplements does not impair iron absorption increases serum BDNF levels in healthy adults in a randomized trial. Nutrients, Lorinzova et al., 2021.<\/p>\n<p><b>Inflammation Study \u2013 HydroCurc\u00ae + iron:<\/b>\u00a0Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress in a placebo-controlled randomized study. Nutrients, Lorinzova et al., 2022.<\/p>\n<p><b>Joint Study \u2013 HydroCurc\u00ae:\u00a0<\/b>The effect of a dispersible curcumin (HydroCurc\u00ae) compared to a placebo for reducing joint pain in a adult population \u2013 a randomized, double-blind study. Complement Med Res, Briskey et al., 2022.<\/p>\n<p><b>Covid-19 Study \u2013 HydroCurc\u00ae:\u00a0<\/b>Curcumin confers anti-inflammatory effects in adults who recovered form COVID-19 and were subsequently vaccinated : a randomized controlled trial. Nutrients, Fessler et al., 2023.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-14\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-14\"><span class=\"accordion-name\">Resveratrol<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-14\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><strong>Verite Trans-resveratrol (oral and topical):<\/strong>\u00a0 Trans-resveratrol treatment can help improve skin health parameters.\u00a0 reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial. Fronties in Aging, Rao et al., 2025.<\/p>\n<p><strong>A comprehensive and systematic review on resveratrol supplementation<\/strong>\u00a0as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical studies. Front. Pharmacol., Xiao-Lin et al., 2025.<\/p>\n<p><b>PK study \u2013 Veri Sperse\u00ae:\u00a0<\/b>Trans-resveratrol oral bioavailability in human using LipiSperse\u00ae dispersion technology. Pharmaceutics, Briskey, 2020.<\/p>\n<p><b>Cerebrovascular and Cognitive study:\u00a0<\/b>Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Nutrients, Zaw et al., 2020.<\/p>\n<p><b>Diabetes type 2 study:<\/b>\u00a0Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond), Zhu et al.,2017.<\/p>\n<p><b>Vascular system study:<\/b>\u00a0Resveratrol and Its Effects on the Vascular System. Int J Mol Sci, Breuss et al., 2019.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-15\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-15\"><span class=\"accordion-name\">Menaquinone-7<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-15\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Randomized Controlled Trial \u2013 Prevention of bone loss:\u00a0<\/b>Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int, Knapen et al., 2013.<\/p>\n<p><b>Multicenter Randomized Controlled Trial \u2013 Chronic hemodialysis and diabetic patients:<\/b>\u00a0Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. Nutrients, Naiyarakseree et al., 2023.<\/p>\n<p><b>Clinical trial, cardiovascular, arteries:\u00a0<\/b>Effect of Menaquinone-7 (vitamin K2) on vascular elasticity in healthy subjects: results from a one-year study. Vascular Diseases and Therapeutics, Vermeer, Hik, 2020.<\/p>\n<p><b>Cardiovascular health, diabetes:\u00a0<\/b>Vitamin K2\u2014a neglected player in cardiovascular health: a narrative review. Open Heart (BMJ Journals), Hariri et al., 2021.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_9be04ea0c4537f76c43ca66b938ea563-16\"aria-expanded=\"false\" aria-controls=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-16\"><span class=\"accordion-name\">Vaccinium macrocarpon<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_9be04ea0c4537f76c43ca66b938ea563-16\" class=\"accordion-collapse collapse\"\r\n                            data-bs-parent=\"#accordion-block_9be04ea0c4537f76c43ca66b938ea563\"><div class=\"accordion-body classic-editor\"><p><b>Clinical trial \u2013 Recurring Urinary Infections, Symptoms after Catheterization:\u00a0<\/b>Anthocran\u00ae Phytosome\u00ae: Prevention of Recurring UrinaryInfections and Symptoms after Catheterization. J Dietary Suppl, Cotellese et al. 2021.<\/p>\n<p><b>Clinical trial \u2013 lower urinary tract symptoms:\u00a0<\/b>Fermented whey-based product improves the quality of life of males with moderate lower urinary tract symptoms: A randomized double-blind study. PLOS ONE, Ausmees et al., 2018.<\/p>\n<p><b>Cochrane Database Syst Rev:\u00a0<\/b>Cranberries for preventing urinary tract infections. Williams et al., 2023.<\/p>\n<p><b>Controlled Clinical trial:\u00a0<\/b>Highly standardized cranberry extract supplementation (Anthocran\u00ae) as prophylaxis in young healthy subjects with recurrent urinary tract infections, Eur Rev Med Pharmacol Sci, Ledda, et, 2017.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div class=\"ama-block block-bgcolor full-width\">\n<div class=\"ama-block block-logos\"><div class=\"block__header text-center\"><h2>Awards. Patented ingredients. Cutting-edge technologies.<\/h2><\/div><div class=\"block__body\"><div class=\"d-flex\"><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"50\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/915\/logo-anthocran-170x65.png\" class=\"attachment-170x65\" alt=\"logo-anthocran\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"37\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1323\/logo-verisperse-170x65.png\" class=\"attachment-170x65\" alt=\"logo-verisperse\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"38\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1317\/logo-lipisperse-170x65.png\" class=\"attachment-170x65\" alt=\"logo-lipisperse\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"125\" height=\"65\" 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alt=\"ni-awards-asia-2023\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"84\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1337\/ni-awards-asia-2021-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-asia-2021\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"170\" height=\"36\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1335\/logo-metabolaid-170x65.png\" class=\"attachment-170x65\" alt=\"logo-metabolaid\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"111\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1315\/aquacelle-logo-170x65.png\" class=\"attachment-170x65\" alt=\"aquacelle-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"111\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1293\/magtein-logo-170x65.png\" class=\"attachment-170x65\" alt=\"magtein-logo\" loading=\"lazy\" \/><\/div><div class=\"logo-item\"><img decoding=\"async\" width=\"67\" height=\"65\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/bis-images\/1319\/ni-awards-lipisperse-2019-170x65.png\" class=\"attachment-170x65\" alt=\"ni-awards-lipisperse-2019\" loading=\"lazy\" \/><\/div><\/div><\/div><\/div>\n<\/div>\n\n<div class=\"ama-block block-faqs\"><div class=\"block__header text-center\"><h2>ANSWERS TO ADDITIONAL QUESTIONS FROM CONSUMERS<\/h2><\/div><div class=\"block__body\"><div class=\"accordion\" id=\"accordion-block_7aca9660b4c687a2188e3e32769ef125\"><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125904\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125904\"><span class=\"accordion-name\" itemprop=\"name\">Can PREMIO supplements be taken alongside medications?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125904\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>There are no contraindications when using the recommended daily doses listed on the product label; these amounts do not impact the effectiveness of medications (they neither decrease nor increase their effects).<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125906\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125906\"><span class=\"accordion-name\" itemprop=\"name\">What information should I make sure to read for each supplement?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125906\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>Always read the information under the tabs regarding the optimal daily dose and usage.<\/p>\n<\/div><\/div><\/div><div class=\"accordion-item\" itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\"><button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-block_7aca9660b4c687a2188e3e32769ef125908\" aria-expanded=\"false\" aria-controls=\"collapse-block_7aca9660b4c687a2188e3e32769ef125908\"><span class=\"accordion-name\" itemprop=\"name\">Where are the ingredients sourced from?<\/span><span class=\"accordion-toggle\"><\/span><\/button><div id=\"collapse-block_7aca9660b4c687a2188e3e32769ef125908\" class=\"accordion-collapse collapse\" data-bs-parent=\"#accordion-block_7aca9660b4c687a2188e3e32769ef125\" itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"><div class=\"accordion-body classic-editor\" itemprop=\"text\"><p>As these are premium supplements (for more details on how they differ from others please refer to our website), the active ingredients are sourced directly from internationally recognized and accredited scientific manufacturers through contracts established after our thorough analysis of scientific innovation and health-supporting practical use. This ensures, that products or ingredients from intermediary companies are excluded, as one of our core principles is complete authenticity.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div class=\"ama-block block-txtmedia has-stencil\"><div class=\"block__body\"><div class=\"body__content\">\n\n<h2 class=\"wp-block-heading wp-el\">YOU ARE ALWAYS WELCOME TO ASK QUESTIONS<\/h2>\n\n\n\n<p class=\"wp-el\"><strong>Note! We always recommend consumers to read the entire PREMIO website contents.<\/strong><\/p>\n\n\n\n<p class=\"wp-el\">If you didn\u2019t find the information you were looking for about a PREMIO\u00ae product on the website, please send your question to info(at)premiostore.eu<\/p>\n\n<\/div><div class=\"body__media\"><div class=\"splide ama_light_gallery_block\" data-splide={\"type\":\"fade\",\"arrows\":false,\"pagination\":false}><div class=\"splide__track\"><ul class=\"splide__list\"><li class=\"splide__slide\"><a href=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-1280x712.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"510\" height=\"510\" src=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-510x510.jpg\" class=\"attachment-woocommerce_single size-woocommerce_single\" alt=\"\" srcset=\"https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-510x510.jpg 510w, https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-250x250.jpg 250w, https:\/\/premiostore.eu\/wp-content\/uploads\/2026\/01\/happy-family-walking-on-the-beach-together-young-2025-04-06-10-04-11-utc-80x80.jpg 80w\" sizes=\"auto, (max-width: 510px) 100vw, 510px\" \/><\/a><\/li><\/ul><\/div><\/div><span class=\"bm__icon\"><\/span><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-914","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages\/914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/comments?post=914"}],"version-history":[{"count":0,"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/pages\/914\/revisions"}],"wp:attachment":[{"href":"https:\/\/premiostore.eu\/en\/wp-json\/wp\/v2\/media?parent=914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}