A selection of scientific-clinical studies conducted with world-class formulations

• Berberine aristata

  A clinical trial: Borderline hyperlipidemia preventive management with Berberine PL in asymptomatic prevention of early atherosclerosis. Minerva Gastroenterol, Cesarone et al., 2024.

  A Meta-analysis and Systematic review.The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. J Transl. Med. Nie et al, 2024

  A Systematic Review and Meta-Analysis of Randomized Clinical Trials: Efficacy and Safety of Berberine Alone for Several Metabolic Disorders. Front. Pharmacol. Ye et al,2021.

  A randomized double-blind placebo-controlled clinical trial: Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. European Review Medical and Pharmacological Sciences, Rondanelli et al.,2023.

• Melissa officinalis

  Randomized, double-blinded, placebo-controlled clinical trial – emotional distress and poor sleep conditions: The possible “calming effect” of subchronic supplementation of a standardized phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomized, double-blinded, placebo-controlled clinical trial. Front Pharmacol, Bano et al., 2023.

  Potential neuromodulator for emotional distress and related conditions: An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions. Front Mol Biosci, Kara et al., 2024.

• Hibiscus sabdariffa and Lippia citriodora

  A double-blind, placebo-controlled, randomized clinical study: Effectiveness of a Polyphenol-Enriched Blend on Weight Management and Metabolic Syndrome-Related Parameters in Healthy Overweight Adults, Appl. Sci. Martínez-Rodríguez et al., 2024

  Randomized, placebo-controlled, double-blind clinical study about MetabolAid®: Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food & Function, Boix-Castejon et al., 2018.

  Randomized controlled clinical study: Diferential efects of a combination of Hibiscus sabdarifa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Scientific Reports, Herranz-Lopes et al.,2019.

  Randomized, placebo-controlled, double-blind clinical study:A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects. Foods, Marhuenda et al., 2020.

  Randomized, placebo-controlled, double-blind clinical trial: A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of a Polyphenolic Extract ( Hibiscus sabdariffa and Lippia citriodora) for Reducing Blood Pressure in Prehypertensive and Type 1 Hypertensive Subjects. Molecules, Marhuenda et al., 2021.

  Randomized controlled clinical study:Effect of metabolaid® on pre- and stage 1 hyperten-sive patients: A randomized controlled trial. J Functional Foods, Boix-Castejon et al., 2021.

  Randomized, placebo-controlled, double-blind, cross-over clinical study:Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial. European J Nutrition, Serna et al, 2022.

  Obesity and its complications: Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation (animal study), Nutrients, Lee et al., 2018.

  Gut microbiota-modulating properties of Metabolaid®: Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites. J. Functional Foods, Silva et al., 2022.

  New Mobile App and using Metabolaid®: New App-Based Dietary and Lifestyle Intervention on Weight Loss and Cardiovascular Health, Sensors (Basel) Martínez-Rodríguez et al. 2022. Metabolaid + mobile app (with daily reminders to follow healthy lifestyle recommendations) increased physical activity and overall improved blood pressure and fat mass levels when compared with a group performing the same intervention without mobile application.

• Palmitoylethanolamide

  Levagen+ and acute menstrual pain: Effect of Levagen+ (PEA) compared to a placebo on acute menstrual pain in an adult population – a double-blind, randomised, placebo controlled, cross-over clinical trial (manuscript in preparation, Amanda Rao et al., 2024)

  Levagen+ and Cognitive Function and BDNF: Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults (RDBPC trial), Nutrients, Kim et al.,2024.

  Levagen+ and Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training: The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial, Sport medicine, Huschtscha et al.,2024

  Levagen+ and Allergic Rhinitis: The Effect of Levagen+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis- A Double-Blind Placebo-Controlled Trial, Nutrients, Briskey et al., 2023.

  Levagen+ and diabetic-related peripheral neuropathic pain: A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology, Pickering et al.,2022.

  Levagen+ and Headache Pain: Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial. Food and Nutrition Sciences, Briskey et al., 2022.

  Levagen+ and incidence and symptoms of Upper Respiratory Tract Infection (DBRPC Trial): The Efficacy of Palmitoyl-ethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection—A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients, Rao, et al., 2023.

  Levagen+ and migraine pain: Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study. Pharmaceuticals, 17, 145, Briskey et al., 2024.

  PK study – Levagen®+: Increased absorption of Palmitoylethanolamide using a novel dispersion technology system (LipiSperse®). Nutriceuticals Food Sci, Briskey et al., 2020.

  Clinical Trial – Exercise study Levagen®+: The effect of orally dosed Levagen®+ (palmitoylethanolamide) on exercise recovery in healthy males. Nutrients, Mallard et al., 2020.

  Clinical Trial – Join pain Levagen®+: The effect of a dispersible palmitoylethanolamide Levagen®+ compared to a placebo for reducing joint pain in an adult population. Inflammopharmacology, Steels et al., 2019.

  Sleep study – Levagen®+: Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study, Sleep Sci Pract, Rao et al, 2021.

  Joint/Knee Pain Study – Levagen®+: A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Steels et al., 2019.

  Lifetime Management – Levagen®+ : Palmitoylethanolamide: A natural compound for health management. Int J Mol Sci, Clayton et al., 2021.

  Covid Study – Levagen®+ : Effects of palmitoylethanolamide on proinflammatory markers in adults recently diagnosed with COVID-19. Current Developments in Nutrition, Fessler et al., 2022.

  A systematic review and preliminary metaanalysis of preclinical and clinical evidence. Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence, Front Psychiatry, Colizzi et al.,2022.

  Treatment of Chronic Pain and PEA: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients, Lang-Illievich et al., 2023.

• Magnesium L-threonate

  Randomized Controlled Trial- Cognition, memory, Magtein®:Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems Sleep medicine, X8, Hausenblas et al, 2024.

  A Randomized, Double-Blind, Placebo-Controlled Trial – cognitive impairment, magnesium-L-threonate:Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial, J Alzheimers Dis, Guosong et al, 2016.

  Randomized Controlled Trial- Cognition, memory, magtein: A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, Zhang et al., 2022.

  Randomized Controlled Trial – Cancer pain, constipation: Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients- A randomized, double-blind, placebo-controlled trial, Cancer Med, Wu et al., 2023.

• Quercetin

  Advantages of the LipiSperse® technology platform: patented, supported by human pharmacokinetic studies, award winning (direct communication from company).

  Randomized, placebo-controlled, double-blind parallel-group study: Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci, Yamada et al., 2022.

  Quercetin and different cancers: The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update. Front. Immunol. Lofti et al., 2023.

  Quercetin -inflammation, diabetes and diabetic complications: Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications. Review. Crit. Rev in Food Sci and Nutrition, Yan et, 2022.

  Quercetin and cardiac arrhythmia: Roles and mechanisms of quercetin on cardiac arrhythmia: A review. Biomedicine & Pharmacotherapy, Zou et al., 2022.

  Quercetin – dyslipidemia, hypertension, metabolic syndrome, obesity: Quercetin and metabolic syndrome: A review, Phytother Res, Hosseini et al., 2021.

  Quercetin – diabetes and cancer: Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer. Diseases, Michala, Pritsa, 2022.

• Ubiquinone

  PK Study – AquaCelle® CoQ10: The impact of micelle size and increased absorption of ubiquinone using a novel delivery system (AquaCelle®). David Briskey, Andrew T Sax, Alistair R Mallard, Charlie Ng and Amanda Rao. International Journal of Pharmacokinetics vol.4, no.2. doi.org/10.4155/ipk-2019-0004

• OMEGA-3

  Chronic kidney disease and large metaanalysis: Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ, Ong et al., 2023

  (Conclusion: higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. The results support a favourable role for seafood derived n-3 PUFAs in preventing CKD)

• Nicotinamide riboside

  Randomized clinical trials: Nicotinamide riboside and PAD: Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial, Nature Communications, McDermott et al., 2024.

  Nicotinamide riboside – safety, bioavailability, metabolic disorders, age-associated diseases, COVID-19: Nicotinamide Riboside – The Current State of Research and Therapeutic Uses, Nutrients, Mehmel et al., 2020.

  Muscle mitochondrial biogenesis, gut microbiota: Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv . 2023, Lapatto et al., 2023.

  Clinical trials, Nicotinamide riboside, Physiology, Successful aging: Dietary supplementation with NAD+ -Boosting Compounds in Humans: Current Knowledge and Future Directions, J Gerontology, Freeberg et al., 2023.

  Rheumatoid Arthritis: Preclinical characterization of pharmacological NAD+ boosting as a promising therapeutic approach in Rheumatoid Arthritis. Arthritis Rheumatol, Perez-Sanchez et al.,2023.

  Chronic kidney disease: Randomized crossover clinical trial of coenzyme Q10 and nicotinamide ribosome in chronic kidney disease. JCI Insight. Ahmadi et al., 2023.

• Methylcobalamine

  Methylcobalamin – anemia, fatigue, weakness, memory loss, hyperhomocysteinemia: Ramifications of Vitamin B12 Deficiency and its Beneficial Effects. Int J Innovative Sci Res Technology, Mukherjee et al., 2023.

  Neuropsychiatric aspects: Changes of Serum Homocysteine and Vitamin B12, but Not Folate Are Correlated With Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Case-Control Studies. Front. Psychiatry, Yan et al., 2022.

  Vitamin B12 and Alzheimer’s Disease: Review. Mechanistic Link between Vitamin B12 and Alzheimer’s Disease. Biomolecules, Lauer et al., 2022.

  Frailty syndrome: B12 levels and frailty syndrome. J Frailty, Sarcopenia, Falls. Pyrgioti and Karakousis, 2022.

• Melatonin

  Meta-analysis – Melatonin and sleep quality: Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. J Neurol, Fatemeh et al., 2022

• Curcuma longa

  PK study – HydroCurc®: Increased absorption curcumin using a novel dipersion technology system (LipiSperce®). Eur J Nutr, Briskey et al., 2019.

  Clinical Trial – DOMS study HydroCurc®: Curcumin improves delayed onset muscle soreness and post-exercise lactate accumulation. J Dietary Suppl. Mallard et al., 2020.

  BDNF Study – HydroCurc®: Co-administration of iron and bioavailable curcumin supplement increases serum BDNF levels in healthy adults. Antioxidants, Lorinzova et al., 2020.

  Iron Study – HydroCurc® + iron: Acute administration of bioavailable curcumin alongside ferrous sulfate supplements does not impair iron absorption increases serum BDNF levels in healthy adults in a randomized trial. Nutrients, Lorinzova et al., 2021.

  Inflammation Study – HydroCurc® + iron: Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress in a placebo-controlled randomized study. Nutrients, Lorinzova et al., 2022.

  Joint Study – HydroCurc®: The effect of a dispersible curcumin (HydroCurc®) compared to a placebo for reducing joint pain in a adult population – a randomized, double-blind study. Complement Med Res, Briskey et al., 2022.

  Covid-19 Study – HydroCurc®: Curcumin confers anti-inflammatory effects in adults who recovered form COVID-19 and were subsequently vaccinated : a randomized controlled trial. Nutrients, Fessler et al., 2023.

• Resveratrol

  PK study – Veri Sperse®: Trans-resveratrol oral bioavailability in human using LipiSperse® dispersion technology. Pharmaceutics, Briskey, 2020.

  Cerebrovascular and Cognitive study: Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Nutrients, Zaw et al., 2020.

  Diabetes type 2 study: Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond), Zhu et al.,2017.

  Vascular system study: Resveratrol and Its Effects on the Vascular System. Int J Mol Sci, Breuss et al., 2019.

• Menaquinone-7

  Randomized Controlled Trial – Prevention of bone loss: Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int, Knapen et al., 2013.

  Multicenter Randomized Controlled Trial – Chronic hemodialysis and diabetic patients: Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. Nutrients, Naiyarakseree et al., 2023.

  Clinical trial, cardiovascular, arteries: Effect of Menaquinone-7 (vitamin K2) on vascular elasticity in healthy subjects: results from a one-year study. Vascular Diseases and Therapeutics, Vermeer, Hik, 2020.

  Cardiovascular health, diabetes: Vitamin K2—a neglected player in cardiovascular health: a narrative review. Open Heart (BMJ Journals), Hariri et al., 2021

• Vaccinium macrocarpon

  Clinical trial – Recurring Urinary Infections, Symptoms after Catheterization: Anthocran® Phytosome®: Prevention of Recurring UrinaryInfections and Symptoms after Catheterization. J Dietary Suppl, Cotellese et al. 2021.

  Clinical trial – lower urinary tract symptoms: Fermented whey-based product improves the quality of life of males with moderate lower urinary tract symptoms: A randomized double-blind study. PLOS ONE, Ausmees et al., 2018.

  Cochrane Database Syst Rev: Cranberries for preventing urinary tract infections. Williams et al., 2023.

  Controlled Clinical trial: Highly standardized cranberry extract supplementation (Anthocran®) as prophylaxis in young healthy subjects with recurrent urinary tract infections, Eur Rev Med Pharmacol Sci, Ledda, et, 2017.

Awards. Patented components. Cutting-edge technologies.

Answers to additional questions posed by our consumers

• Can PREMIO supplements be taken alongside medications?

  There are no contraindications when using the recommended daily doses that are stated on the product label; these amounts do not affect the effects of medications (they neither decrease nor increase their effects).

• What information should I definitely read for each preparation?

  Always read the information under the section ADDITIONAL INFORMATION regarding the optimal daily dose and usage.

• Where are the ingredients sourced from?

  Since these are top-tier supplements (see also the explanation of how they differ from other supplements on our website), the active ingredients are sourced directly from internationally recognized and accredited scientific manufacturers under contracts with them (which are established after our systematic scientific innovation and health-supporting practical use analysis). This means that the use of products/ingredients offered by intermediary companies is excluded, as one of our key principles is complete authenticity.

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