Valik maailma tipp-preparaatidega teostatud teadus-kliinilistest uuringutest

• Berberine aristata

  A clinical trial: Borderline hyperlipidemia preventive management with Berberine PL in asymptomatic prevention of early atherosclerosis. Minerva Gastroenterol, Cesarone et al., 2024.

  A Meta-analysis and Systematic review.The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. J Transl. Med. Nie et al, 2024

  A Systematic Review and Meta-Analysis of Randomized Clinical Trials: Efficacy and Safety of Berberine Alone for Several Metabolic Disorders. Front. Pharmacol. Ye et al,2021.

  A randomized double-blind placebo-controlled clinical trial: Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. European Review Medical and Pharmacological Sciences, Rondanelli et al.,2023.

• Melissa officinalis

  Randomized, double-blinded, placebo-controlled clinical trial – emotional distress and poor sleep conditions: The possible “calming effect” of subchronic supplementation of a standardized phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomized, double-blinded, placebo-controlled clinical trial. Front Pharmacol, Bano et al., 2023.

  Potential neuromodulator for emotional distress and related conditions: An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions. Front Mol Biosci, Kara et al., 2024.

• Hibiscus sabdariffa and Lippia citriodora

  A double-blind, placebo-controlled, randomized clinical study: Effectiveness of a Polyphenol-Enriched Blend on Weight Management and Metabolic Syndrome-Related Parameters in Healthy Overweight Adults, Appl. Sci. Martínez-Rodríguez et al., 2024

  Randomized, placebo-controlled, double-blind clinical study about MetabolAid®: Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food & Function, Boix-Castejon et al., 2018.

  Randomized controlled clinical study: Diferential efects of a combination of Hibiscus sabdarifa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Scientific Reports, Herranz-Lopes et al.,2019.

  Randomized, placebo-controlled, double-blind clinical study:A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects. Foods, Marhuenda et al., 2020.

  Randomized, placebo-controlled, double-blind clinical trial: A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of a Polyphenolic Extract ( Hibiscus sabdariffa and Lippia citriodora) for Reducing Blood Pressure in Prehypertensive and Type 1 Hypertensive Subjects. Molecules, Marhuenda et al., 2021.

  Randomized controlled clinical study:Effect of metabolaid® on pre- and stage 1 hyperten-sive patients: A randomized controlled trial. J Functional Foods, Boix-Castejon et al., 2021.

  Randomized, placebo-controlled, double-blind, cross-over clinical study:Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial. European J Nutrition, Serna et al, 2022.

  Obesity and its complications: Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation (animal study), Nutrients, Lee et al., 2018.

  Gut microbiota-modulating properties of Metabolaid®: Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites. J. Functional Foods, Silva et al., 2022.

  New Mobile App and using Metabolaid®: New App-Based Dietary and Lifestyle Intervention on Weight Loss and Cardiovascular Health, Sensors (Basel) Martínez-Rodríguez et al. 2022. Metabolaid + mobile app (with daily reminders to follow healthy lifestyle recommendations) increased physical activity and overall improved blood pressure and fat mass levels when compared with a group performing the same intervention without mobile application.

• Palmitoylethanolamide

  Levagen+ and acute menstrual pain: Effect of Levagen+ (PEA) compared to a placebo on acute menstrual pain in an adult population – a double-blind, randomised, placebo controlled, cross-over clinical trial (manuscript in preparation, Amanda Rao et al., 2024)

  Levagen+ and Cognitive Function and BDNF: Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults (RDBPC trial), Nutrients, Kim et al.,2024.

  Levagen+ and Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training: The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial, Sport medicine, Huschtscha et al.,2024

  Levagen+ and Allergic Rhinitis: The Effect of Levagen+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis- A Double-Blind Placebo-Controlled Trial, Nutrients, Briskey et al., 2023.

  Levagen+ and diabetic-related peripheral neuropathic pain: A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology, Pickering et al.,2022.

  Levagen+ and Headache Pain: Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial. Food and Nutrition Sciences, Briskey et al., 2022.

  Levagen+ and incidence and symptoms of Upper Respiratory Tract Infection (DBRPC Trial): The Efficacy of Palmitoyl-ethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection—A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients, Rao, et al., 2023.

  Levagen+ and migraine pain: Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study. Pharmaceuticals, 17, 145, Briskey et al., 2024.

  PK study – Levagen®+: Increased absorption of Palmitoylethanolamide using a novel dispersion technology system (LipiSperse®). Nutriceuticals Food Sci, Briskey et al., 2020.

  Clinical Trial – Exercise study Levagen®+: The effect of orally dosed Levagen®+ (palmitoylethanolamide) on exercise recovery in healthy males. Nutrients, Mallard et al., 2020.

  Clinical Trial – Join pain Levagen®+: The effect of a dispersible palmitoylethanolamide Levagen®+ compared to a placebo for reducing joint pain in an adult population. Inflammopharmacology, Steels et al., 2019.

  Sleep study – Levagen®+: Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study, Sleep Sci Pract, Rao et al, 2021.

  Joint/Knee Pain Study – Levagen®+: A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Steels et al., 2019.

  Lifetime Management – Levagen®+ : Palmitoylethanolamide: A natural compound for health management. Int J Mol Sci, Clayton et al., 2021.

  Covid Study – Levagen®+ : Effects of palmitoylethanolamide on proinflammatory markers in adults recently diagnosed with COVID-19. Current Developments in Nutrition, Fessler et al., 2022.

  A systematic review and preliminary metaanalysis of preclinical and clinical evidence. Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence, Front Psychiatry, Colizzi et al.,2022.

  Treatment of Chronic Pain and PEA: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients, Lang-Illievich et al., 2023.

• Magnesium L-threonate

  Randomized Controlled Trial- Cognition, memory, Magtein®:Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems Sleep medicine, X8, Hausenblas et al, 2024.

  A Randomized, Double-Blind, Placebo-Controlled Trial – cognitive impairment, magnesium-L-threonate:Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial, J Alzheimers Dis, Guosong et al, 2016.

  Randomized Controlled Trial- Cognition, memory, magtein: A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, Zhang et al., 2022.

  Randomized Controlled Trial – Cancer pain, constipation: Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients- A randomized, double-blind, placebo-controlled trial, Cancer Med, Wu et al., 2023.

• Quercetin

  Advantages of the LipiSperse® technology platform: patented, supported by human pharmacokinetic studies, award winning (direct communication from company).

  Randomized, placebo-controlled, double-blind parallel-group study: Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci, Yamada et al., 2022.

  Quercetin and different cancers: The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update. Front. Immunol. Lofti et al., 2023.

  Quercetin -inflammation, diabetes and diabetic complications: Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications. Review. Crit. Rev in Food Sci and Nutrition, Yan et, 2022.

  Quercetin and cardiac arrhythmia: Roles and mechanisms of quercetin on cardiac arrhythmia: A review. Biomedicine & Pharmacotherapy, Zou et al., 2022.

  Quercetin – dyslipidemia, hypertension, metabolic syndrome, obesity: Quercetin and metabolic syndrome: A review, Phytother Res, Hosseini et al., 2021.

  Quercetin – diabetes and cancer: Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer. Diseases, Michala, Pritsa, 2022.

• Ubiquinone

  PK Study – AquaCelle® CoQ10: The impact of micelle size and increased absorption of ubiquinone using a novel delivery system (AquaCelle®). David Briskey, Andrew T Sax, Alistair R Mallard, Charlie Ng and Amanda Rao. International Journal of Pharmacokinetics vol.4, no.2. doi.org/10.4155/ipk-2019-0004

• OMEGA-3

  Chronic kidney disease and large metaanalysis: Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ, Ong et al., 2023

  (Conclusion: higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. The results support a favourable role for seafood derived n-3 PUFAs in preventing CKD)

• Nicotinamide riboside

  Randomized clinical trials: Nicotinamide riboside and PAD: Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial, Nature Communications, McDermott et al., 2024.

  Nicotinamide riboside – safety, bioavailability, metabolic disorders, age-associated diseases, COVID-19: Nicotinamide Riboside – The Current State of Research and Therapeutic Uses, Nutrients, Mehmel et al., 2020.

  Muscle mitochondrial biogenesis, gut microbiota: Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv . 2023, Lapatto et al., 2023.

  Clinical trials, Nicotinamide riboside, Physiology, Successful aging: Dietary supplementation with NAD+ -Boosting Compounds in Humans: Current Knowledge and Future Directions, J Gerontology, Freeberg et al., 2023.

  Rheumatoid Arthritis: Preclinical characterization of pharmacological NAD+ boosting as a promising therapeutic approach in Rheumatoid Arthritis. Arthritis Rheumatol, Perez-Sanchez et al.,2023.

  Chronic kidney disease: Randomized crossover clinical trial of coenzyme Q10 and nicotinamide ribosome in chronic kidney disease. JCI Insight. Ahmadi et al., 2023.

• Methylcobalamine

  Methylcobalamin – anemia, fatigue, weakness, memory loss, hyperhomocysteinemia: Ramifications of Vitamin B12 Deficiency and its Beneficial Effects. Int J Innovative Sci Res Technology, Mukherjee et al., 2023.

  Neuropsychiatric aspects: Changes of Serum Homocysteine and Vitamin B12, but Not Folate Are Correlated With Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Case-Control Studies. Front. Psychiatry, Yan et al., 2022.

  Vitamin B12 and Alzheimer’s Disease: Review. Mechanistic Link between Vitamin B12 and Alzheimer’s Disease. Biomolecules, Lauer et al., 2022.

  Frailty syndrome: B12 levels and frailty syndrome. J Frailty, Sarcopenia, Falls. Pyrgioti and Karakousis, 2022.

• Melatonin

  Meta-analysis – Melatonin and sleep quality: Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. J Neurol, Fatemeh et al., 2022

• Curcuma longa

  PK study – HydroCurc®: Increased absorption curcumin using a novel dipersion technology system (LipiSperce®). Eur J Nutr, Briskey et al., 2019.

  Clinical Trial – DOMS study HydroCurc®: Curcumin improves delayed onset muscle soreness and post-exercise lactate accumulation. J Dietary Suppl. Mallard et al., 2020.

  BDNF Study – HydroCurc®: Co-administration of iron and bioavailable curcumin supplement increases serum BDNF levels in healthy adults. Antioxidants, Lorinzova et al., 2020.

  Iron Study – HydroCurc® + iron: Acute administration of bioavailable curcumin alongside ferrous sulfate supplements does not impair iron absorption increases serum BDNF levels in healthy adults in a randomized trial. Nutrients, Lorinzova et al., 2021.

  Inflammation Study – HydroCurc® + iron: Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress in a placebo-controlled randomized study. Nutrients, Lorinzova et al., 2022.

  Joint Study – HydroCurc®: The effect of a dispersible curcumin (HydroCurc®) compared to a placebo for reducing joint pain in a adult population – a randomized, double-blind study. Complement Med Res, Briskey et al., 2022.

  Covid-19 Study – HydroCurc®: Curcumin confers anti-inflammatory effects in adults who recovered form COVID-19 and were subsequently vaccinated : a randomized controlled trial. Nutrients, Fessler et al., 2023.

• Resveratrol

  PK study – Veri Sperse®: Trans-resveratrol oral bioavailability in human using LipiSperse® dispersion technology. Pharmaceutics, Briskey, 2020.

  Cerebrovascular and Cognitive study: Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Nutrients, Zaw et al., 2020.

  Diabetes type 2 study: Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond), Zhu et al.,2017.

  Vascular system study: Resveratrol and Its Effects on the Vascular System. Int J Mol Sci, Breuss et al., 2019.

• Menaquinone-7

  Randomized Controlled Trial – Prevention of bone loss: Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int, Knapen et al., 2013.

  Multicenter Randomized Controlled Trial – Chronic hemodialysis and diabetic patients: Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. Nutrients, Naiyarakseree et al., 2023.

  Clinical trial, cardiovascular, arteries: Effect of Menaquinone-7 (vitamin K2) on vascular elasticity in healthy subjects: results from a one-year study. Vascular Diseases and Therapeutics, Vermeer, Hik, 2020.

  Cardiovascular health, diabetes: Vitamin K2—a neglected player in cardiovascular health: a narrative review. Open Heart (BMJ Journals), Hariri et al., 2021

• Vaccinium macrocarpon

  Clinical trial – Recurring Urinary Infections, Symptoms after Catheterization: Anthocran® Phytosome®: Prevention of Recurring UrinaryInfections and Symptoms after Catheterization. J Dietary Suppl, Cotellese et al. 2021.

  Clinical trial – lower urinary tract symptoms: Fermented whey-based product improves the quality of life of males with moderate lower urinary tract symptoms: A randomized double-blind study. PLOS ONE, Ausmees et al., 2018.

  Cochrane Database Syst Rev: Cranberries for preventing urinary tract infections. Williams et al., 2023.

  Controlled Clinical trial: Highly standardized cranberry extract supplementation (Anthocran®) as prophylaxis in young healthy subjects with recurrent urinary tract infections, Eur Rev Med Pharmacol Sci, Ledda, et, 2017.

Võidetud auhinnad. Patentsed komponendid. Tipptehnoloogiad.

VASTUSED TARBIJATE POOLT ESITATUD LISAKÜSIMUSTELE

• Kas PREMIO preparaate võib tarvitada koos ravimitega?

  Toote etiketil soovitatud koguste kasutamisel pole vastunäidustusi, need kogused ei mõjuta ka ravimite toimeid (ei vähenda ega suurenda nende toimeid.)

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  Kuna on tegemist tipp-preparaatidega (vt ka tipp-prepaatide teistest erinevuse selgitust meie kodulehel), siis saadakse toimeained otse rahvusvaheliselt tunnustatud ja akredeeritud teadustootjatelt nendega sõlmitud lepingute alusel (sõlmitakse meiepoolse süsteemse teadusinnovatiivse ja tervist-toetava praktilise kasutamise analüüsi järgselt), st igasuguste vahendamisfirmade poolt pakutavate toodete/ainete kasutamine on välistatud, sest meie üks põhiprintsiipidest on ka täielik autentsus.

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